› 4pka

X-ray diffraction
2.6Å resolution

Crystal structure of patatin aged with diisopropylphosphorofluoridate

Released:
DOI: 10.2210/pdb4pka/pdb
PDB entry 4pka coloured by chain, front view.
PDB entry 4pka coloured by chain, side view.
PDB entry 4pka coloured by chain, top view.
Source organism: Solanum cardiophyllum
Primary publication:
Crystal structure of patatin-17 in complex with aged and non-aged organophosphorus compounds.
Wijeyesakere SJ, Richardson RJ, Stuckey JA
OpenAccess logo PLoS One 9 e108245 (2014)
PMID: 25248161

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-185302 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Patatin-17 Chain: X
Molecule details ›
Chain: X
Length: 373 amino acids
Theoretical weight: 41.39 KDa
Source organism: Solanum cardiophyllum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8LPW4 (Residues: 23-386; Coverage: 100%)
Sequence domains: Patatin-like phospholipase
Structure domains: Cytosolic phospholipase A2 catalytic domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MIS 1 x MIS

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P43212
Unit cell:
a: 52.99Å b: 52.99Å c: 242.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.21 0.278
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Adipose Triglyceride Lipase Regulation: An Overview.
Cerk et al. (2018)
1 more

3 mentions without citation

Neuropathy target esterase (NTE/PNPLA6) and organophosphorus compound-induced delayed neurotoxicity (OPIDN).
Richardson et al. (2020)
2 more