› 4pru

X-ray diffraction
2.2Å resolution

Crystal structure of dimethyllysine hen egg-white lysozyme in complex with sclx4 at 2.2 A resolution

Released:
DOI: 10.2210/pdb4pru/pdb
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Source organism: Gallus gallus
Primary publication:
Structural study of a small molecule receptor bound to dimethyllysine in lysozyme.
McGovern RE, Snarr BD, Lyons JA, McFarlane J, Whiting AL, Paci I, Hof F, Crowley PB
OpenAccess logo Chem Sci 6 442-449 (2015)
PMID: 25530835

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132831 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysozyme C Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 14.52 KDa
Source organism: Gallus gallus
UniProt:
  • Canonical: P00698 (Residues: 19-147; Coverage: 100%)
Gene name: LYZ
Sequence domains: C-type lysozyme/alpha-lactalbumin family
Structure domains: Lysozyme

Ligands and Environments

2 bound ligands:
Ligand T3Y 4 x T3Y
Ligand GOL 2 x GOL
2 modified residues:
Ligand DM0 2 x DM0
Ligand MLY 10 x MLY

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 46.04Å b: 30.28Å c: 95.01Å
α: 90° β: 96.62° γ: 90°
R-values:
R R work R free
0.349 0.18 0.235

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Citations

5 review citations

Moulding calixarenes for biomacromolecule targeting.
Giuliani et al. (2015)
4 more

2 mentions without citation

Atomic Details of Carbon-Based Nanomolecules Interacting with Proteins.
Di Costanzo et al. (2020)
1 more

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