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Crystal structure of potassium-dependent plant-type L-asparaginase from Phaseolus vulgaris in complex with K+ cations

Source organism: Phaseolus vulgaris
Biochemical function: hydrolase activity
Biological process: not assigned
Cellular component: not assigned

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EC 3.5.1.1: Asparaginase

Reaction catalysed:
L-asparagine + H(2)O = L-aspartate + NH(3)
Systematic name:
L-asparagine amidohydrolase
Alternative Name(s):
  • Alpha-asparaginase
  • Asparaginase II
  • Colaspase
  • Crasnitin
  • Elspar
  • L-asparaginase
  • Leunase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01112
Domain description: Asparaginase
Occurring in:
  1. Isoaspartyl peptidase/L-asparaginase 2
  2. Isoaspartyl peptidase/L-asparaginase 2
The deposited structure of PDB entry 4pu6 contains 2 copies of Pfam domain PF01112 (Asparaginase) in Isoaspartyl peptidase/L-asparaginase 2. Showing 1 copy in chain A.
The deposited structure of PDB entry 4pu6 contains 2 copies of Pfam domain PF01112 (Asparaginase) in Isoaspartyl peptidase/L-asparaginase 2. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000246
Domain description: Peptidase T2, asparaginase 2
Occurring in:
  1. Isoaspartyl peptidase/L-asparaginase 2
  2. Isoaspartyl peptidase/L-asparaginase 2
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. Isoaspartyl peptidase/L-asparaginase 2
  2. Isoaspartyl peptidase/L-asparaginase 2

Structure domain

CATH CATH domain
3.60.20.30
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homology: (Glycosyl)asparaginase
Occurring in:
  1. Isoaspartyl peptidase/L-asparaginase 2
The deposited structure of PDB entry 4pu6 contains 2 copies of CATH domain 3.60.20.30 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Isoaspartyl peptidase/L-asparaginase 2. Showing 1 copy in chain B.

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