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Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide beta-branching

Source organism: Bacillus subtilis subsp. subtilis str. 168
Biochemical function: lyase activity
Biological process: antibiotic biosynthetic process
Cellular component: cytoplasm

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00378
Domain description: Enoyl-CoA hydratase/isomerase
Occurring in:
  1. Putative polyketide biosynthesis enoyl-CoA isomerase PksI
The deposited structure of PDB entry 4q1h contains 3 copies of Pfam domain PF00378 (Enoyl-CoA hydratase/isomerase) in Putative polyketide biosynthesis enoyl-CoA isomerase PksI. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR018376
Domain description: Enoyl-CoA hydratase/isomerase, conserved site
Occurring in:
  1. Putative polyketide biosynthesis enoyl-CoA isomerase PksI
IPR001753
Domain description: Enoyl-CoA hydratase/isomerase
Occurring in:
  1. Putative polyketide biosynthesis enoyl-CoA isomerase PksI
IPR029045
Domain description: ClpP/crotonase-like domain superfamily
Occurring in:
  1. Putative polyketide biosynthesis enoyl-CoA isomerase PksI

Structure domains

CATH CATH domains
6.20.390.20
Class: Special
Architecture: Other non-globular
Topology: Light-harvesting Protein
Homology: Light-harvesting Protein
Occurring in:
  1. Putative polyketide biosynthesis enoyl-CoA isomerase PksI
The deposited structure of PDB entry 4q1h contains 2 copies of CATH domain 6.20.390.20 (Light-harvesting Protein) in Putative polyketide biosynthesis enoyl-CoA isomerase PksI. Showing 1 copy in chain A.
3.90.226.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: 2-enoyl-CoA Hydratase; Chain A, domain 1
Homology: 2-enoyl-CoA Hydratase; Chain A, domain 1
Occurring in:
  1. Putative polyketide biosynthesis enoyl-CoA isomerase PksI
The deposited structure of PDB entry 4q1h contains 1 copy of CATH domain 3.90.226.10 (2-enoyl-CoA Hydratase; Chain A, domain 1) in Putative polyketide biosynthesis enoyl-CoA isomerase PksI. Showing 1 copy in chain B.

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