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Crystal structure of Arginyl-tRNA synthetase

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: arginyl-tRNA aminoacylation
Cellular component: cytoplasm

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EC 6.1.1.19: Arginine--tRNA ligase

Reaction catalysed:
ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)
Systematic name:
L-arginine:tRNA(Arg) ligase (AMP-forming)
Alternative Name(s):
  • Arginine translase
  • Arginine-tRNA synthetase
  • Arginyl transfer ribonucleic acid synthetase
  • Arginyl-tRNA synthetase
  • Arginyl-transfer RNA synthetase
  • Arginyl-transfer ribonucleate synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF05746
Domain description: DALR anticodon binding domain
Occurring in:
  1. Arginine--tRNA ligase, cytoplasmic
The deposited structure of PDB entry 4q2y contains 2 copies of Pfam domain PF05746 (DALR anticodon binding domain) in Arginine--tRNA ligase, cytoplasmic. Showing 1 copy in chain B.

PF00750
Domain description: tRNA synthetases class I (R)
Occurring in:
  1. Arginine--tRNA ligase, cytoplasmic
The deposited structure of PDB entry 4q2y contains 2 copies of Pfam domain PF00750 (tRNA synthetases class I (R)) in Arginine--tRNA ligase, cytoplasmic. Showing 1 copy in chain B.

PF03485
Domain description: Arginyl tRNA synthetase N terminal domain
Occurring in:
  1. Arginine--tRNA ligase, cytoplasmic
The deposited structure of PDB entry 4q2y contains 2 copies of Pfam domain PF03485 (Arginyl tRNA synthetase N terminal domain) in Arginine--tRNA ligase, cytoplasmic. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001278
Domain description: Arginine-tRNA ligase
Occurring in:
  1. Arginine--tRNA ligase, cytoplasmic
IPR035684
Domain description: Arginyl-tRNA synthetase, catalytic core domain
Occurring in:
  1. Arginine--tRNA ligase, cytoplasmic
IPR005148
Domain description: Arginyl tRNA synthetase N-terminal domain
Occurring in:
  1. Arginine--tRNA ligase, cytoplasmic
IPR036695
Domain description: Arginyl tRNA synthetase N-terminal domain superfamily
Occurring in:
  1. Arginine--tRNA ligase, cytoplasmic
IPR008909
Domain description: DALR anticodon binding
Occurring in:
  1. Arginine--tRNA ligase, cytoplasmic
IPR009080
Domain description: Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Occurring in:
  1. Arginine--tRNA ligase, cytoplasmic
IPR001412
Domain description: Aminoacyl-tRNA synthetase, class I, conserved site
Occurring in:
  1. Arginine--tRNA ligase, cytoplasmic
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Arginine--tRNA ligase, cytoplasmic

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