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Interactions between anticancer trans-platinum compounds and proteins: crystal structures and ESI-MS spectra of two protein adducts of trans-(dimethylamino)(methylamino)dichloridoplatinum(II).

Messori L, Marzo T, Michelucci E, Russo Krauss I, Navarro-Ranninger C, Quiroga AG, Merlino A
Inorg Chem 53 7806-8 (2014)
Cited: 17 times
EuropePMC logo PMID: 25025479

Abstract

The adducts formed between trans-(dimethylamino)(methylamino)dichloridoplatinum(II), [t-PtCl2(dma)(ma)], and two model proteins, i.e., hen egg white lysozyme and bovine pancreatic ribonuclease, were independently characterized by X-ray crystallography and electrospray ionization mass spectrometry. In these adducts, the Pt(II) center, upon chloride release, coordinates either to histidine or aspartic acid residues while both alkylamino ligands remain bound to the metal. Comparison with the cisplatin derivatives of the same proteins highlights for [t-PtCl2(dma)(ma)] a kind of biomolecular metalation remarkably different from that of cisplatin.

Reviews citing this publication (2)

  1. Preclinical Advances in Theranostics for the Different Molecular Subtypes of Breast Cancer. Fang H, Cavaliere A, Li Z, Huang Y, Marquez-Nostra B. Front Pharmacol 12 627693 (2021)
  2. Tyrosine kinase inhibitors (TKIs) for ovarian cancer treatment: from organic to inorganic chemotherapeutics towards selectivity-a perspective overview. Baglini E, Chiaverini L, Tolbatov I, Taliani S, Da Settimo F, La Mendola D, Barresi E, Marzo T. Biometals (2023)

Articles citing this publication (15)

  1. Cisplatin binding to human serum albumin: a structural study. Ferraro G, Massai L, Messori L, Merlino A. Chem. Commun. (Camb.) 51 9436-9439 (2015)
  2. Interactions of gold-based drugs with proteins: the structure and stability of the adduct formed in the reaction between lysozyme and the cytotoxic gold(III) compound Auoxo3. Russo Krauss I, Messori L, Cinellu MA, Marasco D, Sirignano R, Merlino A. Dalton Trans 43 17483-17488 (2014)
  3. Oxaliplatin vs. cisplatin: competition experiments on their binding to lysozyme. Marasco D, Messori L, Marzo T, Merlino A. Dalton Trans 44 10392-10398 (2015)
  4. Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme. Ferraro G, Pica A, Russo Krauss I, Pane F, Amoresano A, Merlino A. J. Biol. Inorg. Chem. 21 433-442 (2016)
  5. Platinated oligomers of bovine pancreatic ribonuclease: Structure and stability. Picone D, Donnarumma F, Ferraro G, Russo Krauss I, Fagagnini A, Gotte G, Merlino A. J. Inorg. Biochem. 146 37-43 (2015)
  6. Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts. Messori L, Marzo T, Merlino A. J. Inorg. Biochem. 153 136-142 (2015)
  7. Ru-Based CO releasing molecules with azole ligands: interaction with proteins and the CO release mechanism disclosed by X-ray crystallography. Pontillo N, Ferraro G, Messori L, Tamasi G, Merlino A. Dalton Trans 46 9621-9629 (2017)
  8. Protein metalation by metal-based drugs: X-ray crystallography and mass spectrometry studies. Messori L, Merlino A. Chem. Commun. (Camb.) 53 11622-11633 (2017)
  9. Unusual mode of protein binding by a cytotoxic π-arene ruthenium(ii) piano-stool compound containing an O,S-chelating ligand. Hildebrandt J, Görls H, Häfner N, Ferraro G, Dürst M, Runnebaum IB, Weigand W, Merlino A. Dalton Trans 45 12283-12287 (2016)
  10. Interactions of cisplatin analogues with lysozyme: a comparative analysis. Ferraro G, De Benedictis I, Malfitano A, Morelli G, Novellino E, Marasco D. Biometals 30 733-746 (2017)
  11. Platinum(ii) O,S complexes as potential metallodrugs against Cisplatin resistance. Hildebrandt J, Häfner N, Görls H, Kritsch D, Ferraro G, Dürst M, Runnebaum IB, Merlino A, Weigand W. Dalton Trans 45 18876-18891 (2016)
  12. Potent in vitro antiproliferative properties for a triplatinum cluster toward triple negative breast cancer cells. Gabbiani C, Pratesi A, Marchetti L, Casini A, Leoni P, Pillozzi S, Crociani O, Bartoli G, Messori L. J. Inorg. Biochem. 163 318-322 (2016)
  13. Anti-Her2 affibody-decorated arsenene nanosheets induce ferroptosis through depleting intracellular GSH to overcome cisplatin resistance. He P, Xu S, Miao Z, Que Y, Chen Y, Li S, Ma Q, Yang R, Wei W, Zha Z, Hu Y. J Nanobiotechnology 21 203 (2023)
  14. Chemical Modification of Auranofin Yields a New Family of Anticancer Drug Candidates: The Gold(I) Phosphite Analogues. Cirri D, Geri A, Massai L, Mannelli M, Gamberi T, Magherini F, Becatti M, Gabbiani C, Pratesi A, Messori L. Molecules 28 1050 (2023)
  15. Platinum(II) O,S Complexes Inhibit the Aggregation of Amyloid Model Systems. Florio D, Malfitano AM, Di Somma S, Mügge C, Weigand W, Ferraro G, Iacobucci I, Monti M, Morelli G, Merlino A, Marasco D. Int J Mol Sci 20 (2019)


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