› 4qns

X-ray diffraction
1.5Å resolution

Crystal structure of bromodomain from Plasmodium faciparum GCN5, PF3D7_0823300

Released:
DOI: 10.2210/pdb4qns/pdb
PDB entry 4qns coloured by chain, front view.
PDB entry 4qns coloured by chain, side view.
PDB entry 4qns coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Entry authors: Fonseca M, Tallant C, Knapp S, Loppnau P, von Delft F, Wernimont AK, Arrowsmith CH, Edwards AM, Bountra C, Hui R, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-184734 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase GCN5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 106 amino acids
Theoretical weight: 12.62 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8IB67 (Residues: 1356-1460; Coverage: 7%)
Gene name: PF3D7_0823300
Structure domains: Bromodomain-like

Ligands and Environments

3 bound ligands:
Ligand SO4 8 x SO4
Ligand EDO 7 x EDO
Ligand ACT 3 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 50.217Å b: 98.871Å c: 50.439Å
α: 90° β: 109.63° γ: 90°
R-values:
R R work R free
0.158 0.156 0.187
Expression system: Escherichia coli BL21

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