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Crystal structure of EasA, an old yellow enzyme from Aspergillus fumigatus

Source organism: Aspergillus fumigatus Af293
Biochemical function: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Biological process: fumigaclavine C biosynthetic process
Cellular component: not assigned

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EC 1.3.1.100: Chanoclavine-I aldehyde reductase

Reaction catalysed:
Dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + NADPH
Systematic name:
Chanoclavine-I aldehyde:NAD(+) oxidoreductase
Alternative Name(s):
  • EasA (gene name)
  • FgaOx3

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00724
Domain description: NADH:flavin oxidoreductase / NADH oxidase family
Occurring in:
  1. Chanoclavine-I aldehyde reductase easA
The deposited structure of PDB entry 4qnw contains 1 copy of Pfam domain PF00724 (NADH:flavin oxidoreductase / NADH oxidase family) in Chanoclavine-I aldehyde reductase easA. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001155
Domain description: NADH:flavin oxidoreductase/NADH oxidase, N-terminal
Occurring in:
  1. Chanoclavine-I aldehyde reductase easA
IPR045247
Domain description: Oxidoreductase Oye-like
Occurring in:
  1. Chanoclavine-I aldehyde reductase easA
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Chanoclavine-I aldehyde reductase easA

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Chanoclavine-I aldehyde reductase easA
The deposited structure of PDB entry 4qnw contains 1 copy of CATH domain 3.20.20.70 (TIM Barrel) in Chanoclavine-I aldehyde reductase easA. Showing 1 copy in chain A.

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