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Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide

Source organism: Homo sapiens
Biochemical function: protein tyrosine phosphatase activity
Biological process: dephosphorylation
Cellular component: not assigned

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EC 2.7.11.24: Mitogen-activated protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (MAPKK-activated)
Alternative Name(s):
  • C-Jun N-terminal kinase
  • Dp38
  • ERK
  • ERK1
  • ERK2
  • Extracellular signal-regulated kinase
  • JNK
  • JNK3-alpha-1
  • LeMPK3
  • MAP kinase
  • MAP-2 kinase
  • MAPK
  • MBP kinase I
  • MBP kinase II
  • Microtubule-associated protein 2 kinase
  • Microtubule-associated protein kinase
  • Myelin basic protein kinase
  • P38-2
  • P38-delta
  • P42 mitogen-activated protein kinase
  • P42(mapk)
  • P44mpk
  • PMK-1
  • PMK-2
  • PMK-3
  • Pp42
  • Pp44(mapk)
  • SAPK
  • STK26
  • Stress-activated protein kinase

EC 3.1.3.48: Protein-tyrosine-phosphatase

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Systematic name:
Protein-tyrosine-phosphate phosphohydrolase
Alternative Name(s):
  • (Phosphotyrosine)protein phosphatase
  • PPT-phosphatase
  • PTP-phosphatase
  • PTPase
  • Phosphoprotein phosphatase (phosphotyrosine)
  • Phosphotyrosine histone phosphatase
  • Phosphotyrosine phosphatase
  • Phosphotyrosine protein phosphatase
  • Phosphotyrosylprotein phosphatase
  • Protein phosphotyrosine phosphatase
  • Tyrosine O-phosphate phosphatase
  • Tyrosylprotein phosphatase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00102
Domain description: Protein-tyrosine phosphatase
Occurring in:
  1. Tyrosine-protein phosphatase non-receptor type 3
The deposited structure of PDB entry 4qum contains 1 copy of Pfam domain PF00102 (Protein-tyrosine phosphatase) in Tyrosine-protein phosphatase non-receptor type 3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000242
Domain description: Tyrosine-specific protein phosphatase, PTPase domain
Occurring in:
  1. Tyrosine-protein phosphatase non-receptor type 3
IPR029021
Domain description: Protein-tyrosine phosphatase-like
Occurring in:
  1. Tyrosine-protein phosphatase non-receptor type 3
IPR000387
Domain description: Tyrosine-specific protein phosphatases domain
Occurring in:
  1. Tyrosine-protein phosphatase non-receptor type 3
IPR003595
Domain description: Protein-tyrosine phosphatase, catalytic
Occurring in:
  1. Tyrosine-protein phosphatase non-receptor type 3

Structure domain

CATH CATH domain
3.90.190.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Protein-Tyrosine Phosphatase; Chain A
Homology: Protein tyrosine phosphatase superfamily
Occurring in:
  1. Tyrosine-protein phosphatase non-receptor type 3
The deposited structure of PDB entry 4qum contains 1 copy of CATH domain 3.90.190.10 (Protein-Tyrosine Phosphatase; Chain A) in Tyrosine-protein phosphatase non-receptor type 3. Showing 1 copy in chain A.

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