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Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal.

Nossoni Z, Assar Z, Yapici I, Nosrati M, Wang W, Berbasova T, Vasileiou C, Borhan B, Geiger J
Acta Crystallogr D Biol Crystallogr 70 3226-32 (2014)
Related entries: 4qyp, 4qzt, 4qzu

Cited: 13 times
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Abstract

Cellular retinol-binding proteins (CRBPs) I and II, which are members of the intracellular lipid-binding protein (iLBP) family, are retinoid chaperones that are responsible for the intracellular transport and delivery of both retinol and retinal. Although structures of retinol-bound CRBPI and CRBPII are known, no structure of a retinal-bound CRBP has been reported. In addition, the retinol-bound human CRBPII (hCRBPII) structure shows partial occupancy of a noncanonical conformation of retinol in the binding pocket. Here, the structure of retinal-bound hCRBPII and the structure of retinol-bound hCRBPII with retinol fully occupying the binding pocket are reported. It is further shown that the retinoid derivative seen in both the zebrafish CRBP and the hCRBPII structures is likely to be the product of flux-dependent and wavelength-dependent X-ray damage during data collection. The structures of retinoid-bound CRBPs are compared and contrasted, and rationales for the differences in binding affinities for retinal and retinol are provided.

Reviews - 4qyn mentioned but not cited (1)

  1. Functional characterisation of substrate-binding proteins to address nutrient uptake in marine picocyanobacteria. Ford BA, Sullivan GJ, Moore L, Varkey D, Zhu H, Ostrowski M, Mabbutt BC, Paulsen IT, Shah BS. Biochem Soc Trans 49 2465-2481 (2021)

Articles - 4qyn mentioned but not cited (1)

  1. Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal. Nossoni Z, Assar Z, Yapici I, Nosrati M, Wang W, Berbasova T, Vasileiou C, Borhan B, Geiger J. Acta Crystallogr D Biol Crystallogr 70 3226-3232 (2014)


Reviews citing this publication (3)

  1. Retinol-binding protein 2 (RBP2): biology and pathobiology. Blaner WS, Brun PJ, Calderon RM, Golczak M. Crit Rev Biochem Mol Biol 55 197-218 (2020)
  2. Retinol-binding protein 2 (RBP2): More than just dietary retinoid uptake. Plau J, Golczak M, Paik J, Calderon RM, Blaner WS. Biochim Biophys Acta Mol Cell Biol Lipids 1867 159179 (2022)
  3. Impact of Intracellular Lipid Binding Proteins on Endogenous and Xenobiotic Ligand Metabolism and Disposition. Yabut KCB, Isoherranen N. Drug Metab Dispos 51 700-717 (2023)

Articles citing this publication (8)

  1. Ligand Binding Induces Conformational Changes in Human Cellular Retinol-binding Protein 1 (CRBP1) Revealed by Atomic Resolution Crystal Structures. Silvaroli JA, Arne JM, Chelstowska S, Kiser PD, Banerjee S, Golczak M. J Biol Chem 291 8528-8540 (2016)
  2. Light-Activated Reversible Imine Isomerization: Towards a Photochromic Protein Switch. Berbasova T, Santos EM, Nosrati M, Vasileiou C, Geiger JH, Borhan B. Chembiochem 17 407-414 (2016)
  3. Structural and molecular determinants affecting the interaction of retinol with human CRBP1. Menozzi I, Vallese F, Polverini E, Folli C, Berni R, Zanotti G. J Struct Biol 197 330-339 (2017)
  4. Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches. Ghanbarpour A, Pinger C, Esmatpour Salmani R, Assar Z, Santos EM, Nosrati M, Pawlowski K, Spence D, Vasileiou C, Jin X, Borhan B, Geiger JH. J Am Chem Soc 141 17125-17132 (2019)
  5. Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates. Assar Z, Nossoni Z, Wang W, Santos EM, Kramer K, McCornack C, Vasileiou C, Borhan B, Geiger JH. Structure 24 1590-1598 (2016)
  6. Engineering of a Red Fluorogenic Protein/Merocyanine Complex for Live-Cell Imaging. Santos EM, Berbasova T, Wang W, Salmani RE, Sheng W, Vasileiou C, Geiger JH, Borhan B. Chembiochem 21 723-729 (2020)
  7. Human Cellular Retinol Binding Protein II Forms a Domain-Swapped Trimer Representing a Novel Fold and a New Template for Protein Engineering. Ghanbarpour A, Santos EM, Pinger C, Assar Z, Hossaini Nasr S, Vasileiou C, Spence D, Borhan B, Geiger JH. Chembiochem 21 3192-3196 (2020)
  8. Structural Impact of Selected Retinoids on Model Photoreceptor Membranes. Radzin S, Wiśniewska-Becker A, Markiewicz M, Bętkowski S, Furso J, Waresiak J, Grolik J, Sarna T, Pawlak AM. Membranes (Basel) 13 575 (2023)


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