Function and Biology Details
Reaction catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
- Alpha/Beta hydrolase fold
- Spike S1 subunit, receptor binding domain superfamily, betacoronavirus
- Spike (S) protein S1 subunit, receptor-binding domain, HKU4-like
- Peptidase S9, serine active site
- Peptidase S9, prolyl oligopeptidase, catalytic domain
- Dipeptidylpeptidase IV, N-terminal domain
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Dipeptidyl peptidase 4 and Spike protein S1 (preferred)
PDBe Complex ID:
PDB-CPX-107103 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Dipeptidyl peptidase 4
Molecule details ›
Chains: A, C
Length: 734 amino acids
Theoretical weight: 85.29 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Structure domains:
Length: 734 amino acids
Theoretical weight: 85.29 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P27487 (Residues: 39-766; Coverage: 95%)
Sequence domains:
Structure domains:
Spike protein S1
Molecule details ›
Chains: B, D
Length: 246 amino acids
Theoretical weight: 27.02 KDa
Source organism: Tylonycteris bat coronavirus HKU4
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Structure domains:
Length: 246 amino acids
Theoretical weight: 27.02 KDa
Source organism: Tylonycteris bat coronavirus HKU4
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: A3EX94 (Residues: 372-611; Coverage: 18%)
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Structure domains:
