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Crystal structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)benzyl)carbamothioyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid

Source organism: Homo sapiens
Biochemical function: DNA binding
Biological process: DNA replication
Cellular component: nucleus

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF04057
Domain description: Replication factor-A protein 1, N-terminal domain
Occurring in:
  1. Replication protein A 70 kDa DNA-binding subunit, N-terminally processed
The deposited structure of PDB entry 4r4o contains 1 copy of Pfam domain PF04057 (Replication factor-A protein 1, N-terminal domain) in Replication protein A 70 kDa DNA-binding subunit, N-terminally processed. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR007199
Domain description: Replication factor-A protein 1, N-terminal
Occurring in:
  1. Replication protein A 70 kDa DNA-binding subunit, N-terminally processed
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. Replication protein A 70 kDa DNA-binding subunit, N-terminally processed

Structure domain

CATH CATH domain
2.40.50.140
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: Nucleic acid-binding proteins
Occurring in:
  1. Replication protein A 70 kDa DNA-binding subunit, N-terminally processed
The deposited structure of PDB entry 4r4o contains 1 copy of CATH domain 2.40.50.140 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Replication protein A 70 kDa DNA-binding subunit, N-terminally processed. Showing 1 copy in chain A.

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