› 4rik

X-ray diffraction
1.85Å resolution

Amyloid forming segment, AVVTGVTAV, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 69-77

Released:
DOI: 10.2210/pdb4rik/pdb
PDB entry 4rik coloured by chain, front view.
PDB entry 4rik coloured by chain, side view.
PDB entry 4rik coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the toxic core of α-synuclein from invisible crystals.
Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS
Nature 525 486-90 (2015)
PMID: 26352473

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153502 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-synuclein Chain: A
Molecule details ›
Chain: A
Length: 9 amino acids
Theoretical weight: 816 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P37840 (Residues: 69-77; Coverage: 6%)
Gene names: NACP, PARK1, SNCA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 61.864Å b: 4.799Å c: 17.263Å
α: 90° β: 104.13° γ: 90°
R-values:
R R work R free
0.18 0.176 0.221
Expression system: Not provided

Quick links

Citations

128 review citations

Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade.
Chiti et al. (2017)
127 more

6 mentions without citation

Structure of the toxic core of α-synuclein from invisible crystals.
Rodriguez et al. (2015)
5 more