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G303 Circular Permutation of Old Yellow Enzyme

Source organism: Saccharomyces pastorianus
Biochemical function: oxidoreductase activity
Biological process: not assigned
Cellular component: not assigned

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EC 1.6.99.1: NADPH dehydrogenase

Reaction catalysed:
NADPH + acceptor = NADP(+) + reduced acceptor
Systematic name:
NADPH:acceptor oxidoreductase
Alternative Name(s):
  • Diaphorase
  • Dihydronicotinamide adenine dinucleotide phosphate dehydrogenase
  • NADPH diaphorase
  • NADPH(2) diaphorase
  • NADPH(2)-dehydrogenase
  • NADPH-dehydrogenase
  • NADPH-diaphorase
  • NADPH:(acceptor) oxidoreductase
  • OYE
  • Old yellow enzyme
  • Reduced nicotinamide adenine dinucleotide phosphate dehydrogenase
  • TPNH dehydrogenase
  • TPNH-diaphorase
  • Triphosphopyridine diaphorase
  • Triphosphopyridine nucleotide diaphorase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00724
Domain description: NADH:flavin oxidoreductase / NADH oxidase family
Occurring in:
  1. NADPH dehydrogenase 1
The deposited structure of PDB entry 4rnu contains 4 copies of Pfam domain PF00724 (NADH:flavin oxidoreductase / NADH oxidase family) in NADPH dehydrogenase 1. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR001155
Domain description: NADH:flavin oxidoreductase/NADH oxidase, N-terminal
Occurring in:
  1. NADPH dehydrogenase 1
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. NADPH dehydrogenase 1
IPR045247
Domain description: Oxidoreductase Oye-like
Occurring in:
  1. NADPH dehydrogenase 1

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