› 4tul

X-ray diffraction
1.4Å resolution

Crystal structure of monoclonal antibody against neuroblastoma associated antigen.

Released:
DOI: 10.2210/pdb4tul/pdb
PDB entry 4tul coloured by chain, front view.
PDB entry 4tul coloured by chain, side view.
PDB entry 4tul coloured by chain, top view.
Source organisms:
Primary publication:
Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Horwacik I, Golik P, Grudnik P, Kolinski M, Zdzalik M, Rokita H, Dubin G
Mol Cell Proteomics 14 2577-90 (2015)
PMID: 26179345

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211674 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Heavy chain of monoclonal antibody against neuroblastoma associated antigen Chain: H
Molecule details ›
Chain: H
Length: 214 amino acids
Theoretical weight: 22.75 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
Light chain of monoclonal antibody against neuroblastoma associated antigen Chain: L
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 24.25 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
peptide2 Chain: I
Molecule details ›
Chain: I
Length: 17 amino acids
Theoretical weight: 1.63 KDa
Source organism: Phage #D
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand ACT 3 x ACT
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P21
Unit cell:
a: 42.676Å b: 64.167Å c: 78.9Å
α: 90° β: 99.46° γ: 90°
R-values:
R R work R free
0.189 0.188 0.217
Expression systems:
  • Mus musculus
  • Not provided

Quick links

Citations

8 review citations

Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021.
Wu et al. (2022)
7 more

1 mention without citation

Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Horwacik et al. (2015)