› 4u1y

X-ray diffraction
3.9Å resolution

Full length GluA2-FW-(R,R)-2b complex

Released:
DOI: 10.2210/pdb4u1y/pdb
PDB entry 4u1y coloured by chain, front view.
PDB entry 4u1y coloured by chain, side view.
PDB entry 4u1y coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.
Dürr KL, Chen L, Stein RA, De Zorzi R, Folea IM, Walz T, Mchaourab HS, Gouaux E
Cell 158 778-792 (2014)
PMID: 25109876

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 819 amino acids
Theoretical weight: 92.01 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 94%)
  • Best match: P19491-2 (Residues: 25-847)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 3 x NAG
Ligand FWD 4 x FWD
Ligand FWF 2 x FWF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 105.25Å b: 151.44Å c: 330.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.27 0.268 0.304
Expression system: Homo sapiens

Quick links

Citations

30 review citations

The Lysosome as a Regulatory Hub.
Perera et al. (2016)
29 more

6 mentions without citation

Emerging structural insights into the function of ionotropic glutamate receptors.
Karakas et al. (2015)
5 more