› 4u22

X-ray diffraction
1.44Å resolution

GluA2flip sLBD complexed with FW and (R,R)-2b crystal form D

Released:
DOI: 10.2210/pdb4u22/pdb
PDB entry 4u22 coloured by chain, front view.
PDB entry 4u22 coloured by chain, side view.
PDB entry 4u22 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.
Dürr KL, Chen L, Stein RA, De Zorzi R, Folea IM, Walz T, Mchaourab HS, Gouaux E
Cell 158 778-792 (2014)
PMID: 25109876

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.19 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
  • Best match: P19491-2 (Residues: 413-527, 653-796)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand FWD 1 x FWD
Ligand FWF 1 x FWF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21212
Unit cell:
a: 64.17Å b: 91.74Å c: 48.09Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.188 0.217
Expression system: Escherichia coli

Quick links

Citations

31 review citations

The Lysosome as a Regulatory Hub.
Perera et al. (2016)
30 more

1 mention without citation

Proteomic analysis of zebrafish caudal fin regeneration.
Saxena et al. (2012)