› 4uf1

X-ray diffraction
2.3Å resolution

Deerpox virus DPV022 in complex with Bak BH3

Released:
DOI: 10.2210/pdb4uf1/pdb
PDB entry 4uf1 coloured by chain, front view.
PDB entry 4uf1 coloured by chain, side view.
PDB entry 4uf1 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of Deerpox virus-mediated inhibition of apoptosis.
Burton DR, Caria S, Marshall B, Barry M, Kvansakul M
Acta Crystallogr D Biol Crystallogr 71 1593-603 (2015)
PMID: 26249341

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170729 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptosis regulator DPV022 Chain: A
Molecule details ›
Chain: A
Length: 168 amino acids
Theoretical weight: 19.63 KDa
Source organism: Deerpox virus W-1170-84
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q08FX8 (Residues: 1-155; Coverage: 87%)
Gene name: DPV022
Sequence domains: Apoptosis regulator M11L like
Structure domains: Blc2-like
Bcl-2 homologous antagonist/killer Chain: B
Molecule details ›
Chain: B
Length: 26 amino acids
Theoretical weight: 2.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16611 (Residues: 67-92; Coverage: 12%)
Gene names: BAK, BAK1, BCL2L7, CDN1

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P41212
Unit cell:
a: 93.26Å b: 93.26Å c: 45.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.178 0.206
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

6 review citations

The Bcl-2 Family in Host-Virus Interactions.
Kvansakul et al. (2017)
5 more

1 mention without citation

Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk.
Suraweera et al. (2021)