4uf2

X-ray diffraction
3Å resolution

Deerpox virus DPV022 in complex with Bax BH3

Released:
Primary publication:
Structural basis of Deerpox virus-mediated inhibition of apoptosis.
Acta Crystallogr D Biol Crystallogr 71 1593-603 (2015)
PMID: 26249341

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-170514 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptosis regulator DPV022 Chain: A
Molecule details ›
Chain: A
Length: 168 amino acids
Theoretical weight: 19.63 KDa
Source organism: Deerpox virus W-1170-84
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q08FX8 (Residues: 1-155; Coverage: 87%)
Gene name: DPV022
Sequence domains: Apoptosis regulator M11L like
Structure domains: Blc2-like
Apoptosis regulator BAX Chain: B
Molecule details ›
Chain: B
Length: 28 amino acids
Theoretical weight: 3.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q07812 (Residues: 50-77; Coverage: 15%)
Gene names: BAX, BCL2L4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P41212
Unit cell:
a: 92.481Å b: 92.481Å c: 45.529Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.214 0.274
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided