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Mouse Galactocerebrosidase complexed with dideoxy-imino-lyxitol DIL

Source organism: Mus musculus
Biochemical function: hydrolase activity, acting on glycosyl bonds
Biological process: myelination
Cellular component: membrane

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EC 3.2.1.46: Galactosylceramidase

Reaction catalysed:
D-galactosyl-N-acylsphingosine + H(2)O = D-galactose + N-acylsphingosine
Systematic name:
D-galactosyl-N-acylsphingosine galactohydrolase
Alternative Name(s):
  • Beta-galactocerebrosidase
  • Beta-galactosylceramidase
  • Ceramide galactosidase
  • Cerebroside beta-galactosidase
  • Cerebroside galactosidase
  • Galactocerebrosidase
  • Galactocerebroside beta-galactosidase
  • Galactocerebroside galactosidase
  • Galactocerebroside-beta-D-galactosidase
  • Galactocerebroside.beta-galactosidase
  • Galactosylceramidase I
  • Galactosylceramide beta-galactosidase
  • Galactosylceramide.beta-galactosidase
  • Galactosylcerebrosidase
  • Galcerase
  • Lactosylceramidase
  • Lactosylceramidase I

GO terms

Sequence families

Pfam Protein families (Pfam)
PF21708
Domain description: Galactocerebrosidase, C-terminal lectin domain
Occurring in:
  1. Galactocerebrosidase
The deposited structure of PDB entry 4ufk contains 1 copy of Pfam domain PF21708 (Galactocerebrosidase, C-terminal lectin domain) in GALACTOCEREBROSIDASE. Showing 1 copy in chain A.

PF17387
Domain description: Glycosyl hydrolase family 59 central domain
Occurring in:
  1. Galactocerebrosidase
The deposited structure of PDB entry 4ufk contains 1 copy of Pfam domain PF17387 (Glycosyl hydrolase family 59 central domain) in GALACTOCEREBROSIDASE. Showing 1 copy in chain A.

PF02057
Domain description: Glycosyl hydrolase family 59
Occurring in:
  1. Galactocerebrosidase
The deposited structure of PDB entry 4ufk contains 1 copy of Pfam domain PF02057 (Glycosyl hydrolase family 59) in GALACTOCEREBROSIDASE. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001286
Domain description: Glycoside hydrolase, family 59
Occurring in:
  1. Galactocerebrosidase
IPR035394
Domain description: Glycosyl hydrolase family 59, central domain
Occurring in:
  1. Galactocerebrosidase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Galactocerebrosidase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Galactocerebrosidase

Structure domains

CATH CATH domains
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Galactocerebrosidase
The deposited structure of PDB entry 4ufk contains 1 copy of CATH domain 3.20.20.80 (TIM Barrel) in GALACTOCEREBROSIDASE. Showing 1 copy in chain A.
2.60.120.560
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Exo-inulinase; domain 1
Occurring in:
  1. Galactocerebrosidase
The deposited structure of PDB entry 4ufk contains 1 copy of CATH domain 2.60.120.560 (Jelly Rolls) in GALACTOCEREBROSIDASE. Showing 1 copy in chain A.
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Galactocerebrosidase
The deposited structure of PDB entry 4ufk contains 1 copy of CATH domain 3.20.20.70 (TIM Barrel) in GALACTOCEREBROSIDASE. Showing 1 copy in chain A.

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