› 4uim

X-ray diffraction
2.7Å resolution

crystal structure of quinine-dependent Fab 314.3

Released:
DOI: 10.2210/pdb4uim/pdb
PDB entry 4uim coloured by chain, front view.
PDB entry 4uim coloured by chain, side view.
PDB entry 4uim coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3.
Zhu J, Zhu J, Bougie DW, Aster RH, Springer TA
Blood 126 2138-45 (2015)
PMID: 26282540

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213631 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
FAB 314.3 Chains: A, C, E, H
Molecule details ›
Chains: A, C, E, H
Length: 225 amino acids
Theoretical weight: 24.26 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
FAB 314.3 Chains: B, D, F, L
Molecule details ›
Chains: B, D, F, L
Length: 214 amino acids
Theoretical weight: 23.59 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 67.32Å b: 145.24Å c: 101.49Å
α: 90° β: 90.88° γ: 90°
R-values:
R R work R free
0.222 0.222 0.26

Quick links

Citations

5 review citations

Pathophysiology and Diagnosis of Drug-Induced Immune Thrombocytopenia.
Vayne et al. (2020)
4 more

1 mention without citation

Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3.
Zhu et al. (2015)