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Aldehyde Oxidoreductase from Desulfovibrio gigas (MOP), soaked with trans-cinnamaldehyde

Source organism: Megalodesulfovibrio gigas
Biochemical function: 2 iron, 2 sulfur cluster binding
Biological process: not assigned
Cellular component: not assigned

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EC 1.2.99.7: Aldehyde dehydrogenase (FAD-independent)

Reaction catalysed:
An aldehyde + H(2)O + acceptor = a carboxylate + reduced acceptor
Systematic name:
Aldehyde:acceptor oxidoreductase (FAD-independent)
Alternative Name(s):
  • AORDd
  • Aldehyde oxidase
  • Aldehyde oxidoreductase
  • Mop

GO terms

Sequence families

Pfam Protein families (Pfam)
PF20256
Domain description: Molybdopterin cofactor-binding domain
Occurring in:
  1. Aldehyde oxidoreductase
The deposited structure of PDB entry 4usa contains 1 copy of Pfam domain PF20256 (Molybdopterin cofactor-binding domain) in Aldehyde oxidoreductase. Showing 1 copy in chain A.

PF02738
Domain description: Molybdopterin cofactor-binding domain
Occurring in:
  1. Aldehyde oxidoreductase
The deposited structure of PDB entry 4usa contains 1 copy of Pfam domain PF02738 (Molybdopterin cofactor-binding domain) in Aldehyde oxidoreductase. Showing 1 copy in chain A.

PF01315
Domain description: Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
Occurring in:
  1. Aldehyde oxidoreductase
The deposited structure of PDB entry 4usa contains 1 copy of Pfam domain PF01315 (Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain) in Aldehyde oxidoreductase. Showing 1 copy in chain A.

PF01799
Domain description: [2Fe-2S] binding domain
Occurring in:
  1. Aldehyde oxidoreductase
The deposited structure of PDB entry 4usa contains 1 copy of Pfam domain PF01799 ([2Fe-2S] binding domain) in Aldehyde oxidoreductase. Showing 1 copy in chain A.

PF00111
Domain description: 2Fe-2S iron-sulfur cluster binding domain
Occurring in:
  1. Aldehyde oxidoreductase
The deposited structure of PDB entry 4usa contains 1 copy of Pfam domain PF00111 (2Fe-2S iron-sulfur cluster binding domain) in Aldehyde oxidoreductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001041
Domain description: 2Fe-2S ferredoxin-type iron-sulfur binding domain
Occurring in:
  1. Aldehyde oxidoreductase
IPR000674
Domain description: Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
Occurring in:
  1. Aldehyde oxidoreductase
IPR046867
Domain description: Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain
Occurring in:
  1. Aldehyde oxidoreductase
IPR008274
Domain description: Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain
Occurring in:
  1. Aldehyde oxidoreductase
IPR037165
Domain description: Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily
Occurring in:
  1. Aldehyde oxidoreductase
IPR016208
Domain description: Aldehyde oxidase/xanthine dehydrogenase-like
Occurring in:
  1. Aldehyde oxidoreductase
IPR036856
Domain description: Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
Occurring in:
  1. Aldehyde oxidoreductase
IPR036884
Domain description: [2Fe-2S]-binding domain superfamily
Occurring in:
  1. Aldehyde oxidoreductase
IPR002888
Domain description: [2Fe-2S]-binding
Occurring in:
  1. Aldehyde oxidoreductase
IPR006058
Domain description: 2Fe-2S ferredoxin, iron-sulphur binding site
Occurring in:
  1. Aldehyde oxidoreductase
IPR036010
Domain description: 2Fe-2S ferredoxin-like superfamily
Occurring in:
  1. Aldehyde oxidoreductase
IPR012675
Domain description: Beta-grasp domain superfamily
Occurring in:
  1. Aldehyde oxidoreductase

Structure domains

CATH CATH domains
3.30.365.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Aldehyde Oxidoreductase; domain 4
Homology: Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain
Occurring in:
  1. Aldehyde oxidoreductase
The deposited structure of PDB entry 4usa contains 4 copies of CATH domain 3.30.365.10 (Aldehyde Oxidoreductase; domain 4) in Aldehyde oxidoreductase. Showing 4 copies in chain A.
3.90.1170.50
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aldehyde Oxidoreductase; domain 3
Homology: Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
Occurring in:
  1. Aldehyde oxidoreductase
The deposited structure of PDB entry 4usa contains 1 copy of CATH domain 3.90.1170.50 (Aldehyde Oxidoreductase; domain 3) in Aldehyde oxidoreductase. Showing 1 copy in chain A.
1.10.150.120
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: [2Fe-2S]-binding domain
Occurring in:
  1. Aldehyde oxidoreductase
The deposited structure of PDB entry 4usa contains 1 copy of CATH domain 1.10.150.120 (DNA polymerase; domain 1) in Aldehyde oxidoreductase. Showing 1 copy in chain A.
3.10.20.30
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Ubiquitin-like (UB roll)
Occurring in:
  1. Aldehyde oxidoreductase
The deposited structure of PDB entry 4usa contains 1 copy of CATH domain 3.10.20.30 (Ubiquitin-like (UB roll)) in Aldehyde oxidoreductase. Showing 1 copy in chain A.

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