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Human dynamin 1 K44A superconstricted polymer stabilized with GTP strand 2

Source organism: Homo sapiens
Biochemical function: protein homodimerization activity
Biological process: vesicle scission
Cellular component: glutamatergic synapse

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EC 3.6.5.5: Dynamin GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (vesicle-releasing)

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF02212
Domain description: Dynamin GTPase effector domain
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
The deposited structure of PDB entry 4uuk contains 4 copies of Pfam domain PF02212 (Dynamin GTPase effector domain) in Dynamin-1. Showing 1 copy in chain K.
The deposited structure of PDB entry 4uuk contains 8 copies of Pfam domain PF02212 (Dynamin GTPase effector domain) in Dynamin-1. Showing 1 copy in chain J.

PF00169
Domain description: PH domain
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
The deposited structure of PDB entry 4uuk contains 4 copies of Pfam domain PF00169 (PH domain) in Dynamin-1. Showing 1 copy in chain K (this domain is out of the observed residue ranges!).
The deposited structure of PDB entry 4uuk contains 8 copies of Pfam domain PF00169 (PH domain) in Dynamin-1. Showing 1 copy in chain J (this domain is out of the observed residue ranges!).

PF01031
Domain description: Dynamin central region
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
The deposited structure of PDB entry 4uuk contains 4 copies of Pfam domain PF01031 (Dynamin central region) in Dynamin-1. Showing 1 copy in chain K.
The deposited structure of PDB entry 4uuk contains 8 copies of Pfam domain PF01031 (Dynamin central region) in Dynamin-1. Showing 1 copy in chain J.

PF00350
Domain description: Dynamin family
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
The deposited structure of PDB entry 4uuk contains 4 copies of Pfam domain PF00350 (Dynamin family) in Dynamin-1. Showing 1 copy in chain K.
The deposited structure of PDB entry 4uuk contains 8 copies of Pfam domain PF00350 (Dynamin family) in Dynamin-1. Showing 1 copy in chain J (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR022812
Domain description: Dynamin
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
IPR001849
Domain description: Pleckstrin homology domain
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
IPR003130
Domain description: Dynamin GTPase effector
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
IPR001401
Domain description: Dynamin, GTPase domain
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
IPR020850
Domain description: GTPase effector domain
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
IPR000375
Domain description: Dynamin stalk domain
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
IPR019762
Domain description: Dynamin, GTPase region, conserved site
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
IPR045063
Domain description: Dynamin, N-terminal
Occurring in:
  1. Dynamin-1
  2. Dynamin-1
IPR030381
Domain description: Dynamin-type guanine nucleotide-binding (G) domain
Occurring in:
  1. Dynamin-1
  2. Dynamin-1

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