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Ternary complex among two human derived single chain antibody fragments and Cn2 toxin from scorpion Centruroides noxius.

Source organisms:
Biochemical function: toxin activity
Biological process: modulation of process of another organism
Cellular component: extracellular region

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00537
Domain description: Scorpion toxin-like domain
Occurring in:
  1. Beta-mammal toxin Cn2
The deposited structure of PDB entry 4v1d contains 1 copy of Pfam domain PF00537 (Scorpion toxin-like domain ) in Beta-mammal toxin Cn2. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. SINGLE CHAIN ANTIBODY FRAGMENT LR, HEAVY CHAIN
  2. SINGLE CHAIN ANTIBODY FRAGMENT LR, LIGHT CHAIN
  3. SINGLE CHAIN ANTIBODY FRAGMENT RU1, HEAVY CHAIN
  4. SINGLE CHAIN ANTIBODY FRAGMENT RU1, LIGHT CHAIN
IPR018218
Domain description: Scorpion long chain toxin
Occurring in:
  1. Beta-mammal toxin Cn2
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. SINGLE CHAIN ANTIBODY FRAGMENT LR, HEAVY CHAIN
  2. SINGLE CHAIN ANTIBODY FRAGMENT LR, LIGHT CHAIN
  3. SINGLE CHAIN ANTIBODY FRAGMENT RU1, HEAVY CHAIN
  4. SINGLE CHAIN ANTIBODY FRAGMENT RU1, LIGHT CHAIN
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. SINGLE CHAIN ANTIBODY FRAGMENT LR, HEAVY CHAIN
  2. SINGLE CHAIN ANTIBODY FRAGMENT LR, LIGHT CHAIN
  3. SINGLE CHAIN ANTIBODY FRAGMENT RU1, HEAVY CHAIN
  4. SINGLE CHAIN ANTIBODY FRAGMENT RU1, LIGHT CHAIN
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. SINGLE CHAIN ANTIBODY FRAGMENT LR, HEAVY CHAIN
  2. SINGLE CHAIN ANTIBODY FRAGMENT LR, LIGHT CHAIN
  3. SINGLE CHAIN ANTIBODY FRAGMENT RU1, HEAVY CHAIN
  4. SINGLE CHAIN ANTIBODY FRAGMENT RU1, LIGHT CHAIN
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. SINGLE CHAIN ANTIBODY FRAGMENT LR, HEAVY CHAIN
  2. SINGLE CHAIN ANTIBODY FRAGMENT LR, LIGHT CHAIN
  3. SINGLE CHAIN ANTIBODY FRAGMENT RU1, HEAVY CHAIN
  4. SINGLE CHAIN ANTIBODY FRAGMENT RU1, LIGHT CHAIN
IPR036574
Domain description: Knottin, scorpion toxin-like superfamily
Occurring in:
  1. Beta-mammal toxin Cn2
IPR044062
Domain description: LCN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain
Occurring in:
  1. Beta-mammal toxin Cn2
IPR003614
Domain description: Knottin, scorpion toxin-like
Occurring in:
  1. Beta-mammal toxin Cn2
IPR002061
Domain description: Scorpion long chain toxin/defensin
Occurring in:
  1. Beta-mammal toxin Cn2

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. SINGLE CHAIN ANTIBODY FRAGMENT LR, HEAVY CHAIN
  2. SINGLE CHAIN ANTIBODY FRAGMENT LR, LIGHT CHAIN
  3. SINGLE CHAIN ANTIBODY FRAGMENT RU1, HEAVY CHAIN
  4. SINGLE CHAIN ANTIBODY FRAGMENT RU1, LIGHT CHAIN
The deposited structure of PDB entry 4v1d contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in SINGLE CHAIN ANTIBODY FRAGMENT LR, HEAVY CHAIN. Showing 1 copy in chain A.
The deposited structure of PDB entry 4v1d contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in SINGLE CHAIN ANTIBODY FRAGMENT LR, LIGHT CHAIN. Showing 1 copy in chain B.
The deposited structure of PDB entry 4v1d contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in SINGLE CHAIN ANTIBODY FRAGMENT RU1, HEAVY CHAIN. Showing 1 copy in chain D.
The deposited structure of PDB entry 4v1d contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in SINGLE CHAIN ANTIBODY FRAGMENT RU1, LIGHT CHAIN. Showing 1 copy in chain E.
3.30.30.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Defensin A-like
Homology: Knottin, scorpion toxin-like
Occurring in:
  1. Beta-mammal toxin Cn2
The deposited structure of PDB entry 4v1d contains 1 copy of CATH domain 3.30.30.10 (Defensin A-like) in Beta-mammal toxin Cn2. Showing 1 copy in chain C.

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