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Crystal Structure of tRNA-dihydrouridine(20) synthase catalytic domain

Source organism: Homo sapiens
Biochemical function: flavin adenine dinucleotide binding
Biological process: tRNA processing
Cellular component: not assigned

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EC 1.3.1.91: tRNA-dihydrouridine(20) synthase (NAD(P)(+))

Reaction catalysed:
5,6-dihydrouracil(20) in tRNA + NAD(P)(+) = uracil(20) in tRNA + NAD(P)H
Systematic name:
tRNA-5,6-dihydrouracil(20):NAD(P)(+) oxidoreductase
Alternative Name(s):
  • Dus2p
  • tRNA-dihydrouridine synthase 2

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01207
Domain description: Dihydrouridine synthase (Dus)
Occurring in:
  1. tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
The deposited structure of PDB entry 4wfs contains 1 copy of Pfam domain PF01207 (Dihydrouridine synthase (Dus)) in tRNA-dihydrouridine(20) synthase [NAD(P)+]-like. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR035587
Domain description: DUS-like, FMN-binding domain
Occurring in:
  1. tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
IPR018517
Domain description: tRNA-dihydrouridine synthase, conserved site
Occurring in:
  1. tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
IPR001269
Domain description: tRNA-dihydrouridine synthase
Occurring in:
  1. tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

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