› 4wnq

X-ray diffraction
1.8Å resolution

THE MOLECULAR BASES OF DELTA/ALPHA-BETA T-CELL MEDIATED ANTIGEN RECOGNITION

Released:
DOI: 10.2210/pdb4wnq/pdb
PDB entry 4wnq coloured by chain, front view.
PDB entry 4wnq coloured by chain, side view.
PDB entry 4wnq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The molecular bases of δ/αβ T cell-mediated antigen recognition.
Pellicci DG, Uldrich AP, Le Nours J, Ross F, Chabrol E, Eckle SB, de Boer R, Lim RT, McPherson K, Besra G, Howell AR, Moretta L, McCluskey J, Heemskerk MH, Gras S, Rossjohn J, Godfrey DI
OpenAccess logo J Exp Med 211 2599-615 (2014)
PMID: 25452463

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213642 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
TCR Variable Delta 1 chain and TCR constant Alpha chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 207 amino acids
Theoretical weight: 23.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
TCR Variable Beta 2 (TRBV20) chain and TCR constant Beta chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 245 amino acids
Theoretical weight: 27.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P1
Unit cell:
a: 39.257Å b: 47.235Å c: 109.29Å
α: 88.32° β: 79.78° γ: 89.93°
R-values:
R R work R free
0.195 0.193 0.229
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge.
Pellicci et al. (2020)
19 more

1 mention without citation

The molecular bases of δ/αβ T cell-mediated antigen recognition.
Pellicci et al. (2014)