› 4wtx

X-ray diffraction
1.5Å resolution

Crystal structure of the fourth FnIII domain of integrin beta4

Released:
DOI: 10.2210/pdb4wtx/pdb
PDB entry 4wtx coloured by chain, front view.
PDB entry 4wtx coloured by chain, side view.
PDB entry 4wtx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Combination of X-ray crystallography, SAXS and DEER to obtain the structure of the FnIII-3,4 domains of integrin α6β4.
Alonso-García N, García-Rubio I, Manso JA, Buey RM, Urien H, Sonnenberg A, Jeschke G, de Pereda JM
OpenAccess logo Acta Crystallogr D Biol Crystallogr 71 969-85 (2015)
PMID: 25849406

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin beta-4 Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 10.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16144 (Residues: 1642-1736; Coverage: 5%)
Gene name: ITGB4
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P41212
Unit cell:
a: 57.26Å b: 57.26Å c: 76.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.195 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

The opposing roles of laminin-binding integrins in cancer.
Ramovs et al. (2017)
1 more

2 mentions without citation

MMM: A toolbox for integrative structure modeling.
Jeschke G. (2018)
1 more