Function and Biology

Crystal structure of a chimeric Murine Norovirus NS6 protease (inactive C139A mutant) in which the P4-P4 prime residues of the cleavage junction in the extended C-terminus have been replaced by the corresponding residues from the NS2-3 junction.

Source organism: Murine norovirus 1
Biochemical function: cysteine-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

EC 3.4.22.66: Calicivirin

Reaction catalysed:
Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|- and the P1' position is occupied by Gly-|-
Systematic name:
-
Alternative Name(s):
  • Calicivirus 3C-like protease
  • Calicivirus TCP
  • Calicivirus endopeptidase
  • Calicivirus trypsin-like cysteine protease
  • Camberwell virus processing peptidase
  • Chiba virus processing peptidase
  • Norovirus virus processing peptidase
  • Norwalk virus processing peptidase
  • Rabbit hemorrhagic disease virus 3C endopeptidase
  • Southampton virus
  • Southampton virus processing peptidase

EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF05416
Domain description: Southampton virus-type processing peptidase
Occurring in:
  1. 3C-like protease
The deposited structure of PDB entry 4x2y contains 2 copies of Pfam domain PF05416 (Southampton virus-type processing peptidase) in NS6 Protease,NS6 Protease. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001665
Domain description: Norovirus peptidase C37
Occurring in:
  1. 3C-like protease
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. 3C-like protease
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. 3C-like protease

Structure domain

CATH CATH domain
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. 3C-like protease
The deposited structure of PDB entry 4x2y contains 4 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in NS6 Protease,NS6 Protease. Showing 2 copies in chain B.