Function and Biology

Structure of dextran glucosidase

Source organism: Streptococcus mutans UA159
Biochemical function: glucan 1,6-alpha-glucosidase activity
Biological process: oligosaccharide catabolic process
Cellular component: cytoplasm

EC 3.2.1.70: Glucan 1,6-alpha-glucosidase

Reaction catalysed:
Hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides
Systematic name:
Glucan 6-alpha-D-glucohydrolase
Alternative Name(s):
  • Exo-1,6-alpha-glucosidase
  • Exo-1,6-beta-glucosidase
  • Glucan alpha-1,6-D-glucohydrolase
  • Glucodextranase
  • Glucodextrinase

Sequence family

Pfam Protein family (Pfam)
PF00128
Domain description: Alpha amylase, catalytic domain
Occurring in:
  1. Glucan 1,6-alpha-glucosidase
The deposited structure of PDB entry 4xb3 contains 1 copy of Pfam domain PF00128 (Alpha amylase, catalytic domain) in Glucan 1,6-alpha-glucosidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006047
Domain description: Glycosyl hydrolase, family 13, catalytic domain
Occurring in:
  1. Glucan 1,6-alpha-glucosidase
IPR013780
Domain description: Glycosyl hydrolase, all-beta
Occurring in:
  1. Glucan 1,6-alpha-glucosidase
IPR045857
Domain description: Oligo-1,6-glucosidase, domain 2
Occurring in:
  1. Glucan 1,6-alpha-glucosidase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Glucan 1,6-alpha-glucosidase

Structure domains

CATH CATH domains
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Glucan 1,6-alpha-glucosidase
The deposited structure of PDB entry 4xb3 contains 1 copy of CATH domain 3.20.20.80 (TIM Barrel) in Glucan 1,6-alpha-glucosidase. Showing 1 copy in chain A.
2.60.40.1180
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Golgi alpha-mannosidase II
Occurring in:
  1. Glucan 1,6-alpha-glucosidase
The deposited structure of PDB entry 4xb3 contains 1 copy of CATH domain 2.60.40.1180 (Immunoglobulin-like) in Glucan 1,6-alpha-glucosidase. Showing 1 copy in chain A.
3.90.400.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Oligo-1,6-glucosidase; domain 2
Homology: Oligo-1,6-glucosidase; Domain 2
Occurring in:
  1. Glucan 1,6-alpha-glucosidase
The deposited structure of PDB entry 4xb3 contains 1 copy of CATH domain 3.90.400.10 (Oligo-1,6-glucosidase; domain 2) in Glucan 1,6-alpha-glucosidase. Showing 1 copy in chain A.