› 4xgo

X-ray diffraction
1.74Å resolution

Crystal structure of leucine-rich repeat domain of APL1B

Released:
DOI: 10.2210/pdb4xgo/pdb
PDB entry 4xgo coloured by chain, front view.
PDB entry 4xgo coloured by chain, side view.
PDB entry 4xgo coloured by chain, top view.
Source organism: Anopheles gambiae
Primary publication:
Biophysical analysis of anopheles gambiae leucine-rich repeat proteins APL1A1, APL1B [corrected] and APL1C and their interaction with LRIM1.
Williams M, Summers BJ, Baxter RH
OpenAccess logo PLoS One 10 e0118911 (2015)
PMID: 25775123

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123427 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
LRIM1/APL1C-like dimerization domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 356 amino acids
Theoretical weight: 41.09 KDa
Source organism: Anopheles gambiae
Expression system: Trichoplusia ni
UniProt:
  • Canonical: F2YBL9 (Residues: 21-370; Coverage: 65%)
Gene name: APL1B
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
5 bound ligands:
Ligand PO4 3 x PO4
Ligand ACT 2 x ACT
Ligand GOL 6 x GOL
Ligand CL 2 x CL
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P212121
Unit cell:
a: 64.423Å b: 74.956Å c: 214.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.22
Expression system: Trichoplusia ni

Quick links

Citations

2 review citations

Mosquito gut antiparasitic and antiviral immunity.
Saraiva et al. (2016)
1 more

1 mention without citation

Biophysical analysis of anopheles gambiae leucine-rich repeat proteins APL1A1, APL1B [corrected] and APL1C and their interaction with LRIM1.
Williams et al. (2015)