EC 2.7.7.7: DNA-directed DNA polymerase
Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
- DNA duplicase
- DNA nucleotidyltransferase
- DNA nucleotidyltransferase (DNA-directed)
- DNA polymerase
- DNA polymerase I
- DNA polymerase II
- DNA polymerase III
- DNA polymerase alpha
- DNA polymerase beta
- DNA polymerase gamma
- DNA replicase
- DNA-dependent DNA polymerase
- Deoxynucleate polymerase
- Deoxyribonucleate nucleotidyltransferase
- Deoxyribonucleic acid duplicase
- Deoxyribonucleic acid polymerase
- Deoxyribonucleic duplicase
- Deoxyribonucleic polymerase
- Deoxyribonucleic polymerase I
- Duplicase
- Klenow fragment
- Sequenase
- Taq DNA polymerase
- Taq Pol I
- Tca DNA polymerase
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)![The deposited structure of PDB entry 4xq8 contains 2 copies of Pfam domain PF14791 (DNA polymerase beta thumb ) in DNA polymerase lambda. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/4xq8_1_B_Pfam_PF14791_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4xq8</span> contains 2 copies of Pfam domain <span class='highlight'>PF14791 (DNA polymerase beta thumb )</span> in <span class='highlight'>DNA polymerase lambda</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")
![The deposited structure of PDB entry 4xq8 contains 2 copies of Pfam domain PF14792 (DNA polymerase beta palm ) in DNA polymerase lambda. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/4xq8_1_B_Pfam_PF14792_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4xq8</span> contains 2 copies of Pfam domain <span class='highlight'>PF14792 (DNA polymerase beta palm )</span> in <span class='highlight'>DNA polymerase lambda</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")
![The deposited structure of PDB entry 4xq8 contains 2 copies of Pfam domain PF10391 (Fingers domain of DNA polymerase lambda) in DNA polymerase lambda. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/4xq8_1_B_Pfam_PF10391_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4xq8</span> contains 2 copies of Pfam domain <span class='highlight'>PF10391 (Fingers domain of DNA polymerase lambda)</span> in <span class='highlight'>DNA polymerase lambda</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")
![The deposited structure of PDB entry 4xq8 contains 2 copies of Pfam domain PF14716 (Helix-hairpin-helix domain) in DNA polymerase lambda. Showing 1 copy in chain A [auth B] (this domain is out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/4xq8_1_B_Pfam_PF14716_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4xq8</span> contains 2 copies of Pfam domain <span class='highlight'>PF14716 (Helix-hairpin-helix domain)</span> in <span class='highlight'>DNA polymerase lambda</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span> (this domain is out of the observed residue ranges!).")
InterPro annotationsStructure domains
CATH domains
3.30.210.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Beta Polymerase; domain 3
Homology:
DNA polymerase, thumb domain
Occurring in:
![The deposited structure of PDB entry 4xq8 contains 2 copies of CATH domain 3.30.210.10 (Beta Polymerase; domain 3) in DNA polymerase lambda. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/4xq8_1_B_CATH_3.30.210.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4xq8</span> contains 2 copies of CATH domain <span class='highlight'>3.30.210.10 (Beta Polymerase; domain 3)</span> in <span class='highlight'>DNA polymerase lambda</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")
3.30.460.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Beta Polymerase; domain 2
Homology:
Beta Polymerase, domain 2
Occurring in:
![The deposited structure of PDB entry 4xq8 contains 2 copies of CATH domain 3.30.460.10 (Beta Polymerase; domain 2) in DNA polymerase lambda. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/4xq8_1_B_CATH_3.30.460.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4xq8</span> contains 2 copies of CATH domain <span class='highlight'>3.30.460.10 (Beta Polymerase; domain 2)</span> in <span class='highlight'>DNA polymerase lambda</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")
![The deposited structure of PDB entry 4xq8 contains 2 copies of CATH domain 1.10.150.20 (DNA polymerase; domain 1) in DNA polymerase lambda. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/4xq8_1_B_CATH_1.10.150.20_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4xq8</span> contains 2 copies of CATH domain <span class='highlight'>1.10.150.20 (DNA polymerase; domain 1)</span> in <span class='highlight'>DNA polymerase lambda</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")