Function and Biology

Binary complex of human polymerase nu and DNA with the finger domain closed

Source organism: Homo sapiens
Biochemical function: DNA-directed DNA polymerase activity
Biological process: DNA-templated DNA replication
Cellular component: not assigned

EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00476
Domain description: DNA polymerase family A
Occurring in:
  1. DNA polymerase nu
The deposited structure of PDB entry 4xvk contains 1 copy of Pfam domain PF00476 (DNA polymerase family A) in DNA polymerase nu. Showing 1 copy in chain A.

PF18049
Domain description: DNA polymerase nu pseudo-exo
Occurring in:
  1. DNA polymerase nu
The deposited structure of PDB entry 4xvk contains 1 copy of Pfam domain PF18049 (DNA polymerase nu pseudo-exo) in DNA polymerase nu. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002298
Domain description: DNA polymerase A
Occurring in:
  1. DNA polymerase nu
IPR001098
Domain description: DNA-directed DNA polymerase, family A, palm domain
Occurring in:
  1. DNA polymerase nu
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. DNA polymerase nu
IPR036397
Domain description: Ribonuclease H superfamily
Occurring in:
  1. DNA polymerase nu
IPR040940
Domain description: DNA polymerase nu, pseudo-exo domain
Occurring in:
  1. DNA polymerase nu