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Crystal structure of an acyl-ACP dehydrogenase

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: enoyl-[acyl-carrier-protein] reductase (NADPH) activity
Biological process: fatty acid beta-oxidation using acyl-CoA dehydrogenase
Cellular component: cytoplasm

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00441
Domain description: Acyl-CoA dehydrogenase, C-terminal domain
Occurring in:
  1. Acyl-[acyl-carrier-protein] dehydrogenase MbtN
The deposited structure of PDB entry 4xvx contains 2 copies of Pfam domain PF00441 (Acyl-CoA dehydrogenase, C-terminal domain) in Acyl-[acyl-carrier-protein] dehydrogenase MbtN. Showing 1 copy in chain B.

PF02770
Domain description: Acyl-CoA dehydrogenase, middle domain
Occurring in:
  1. Acyl-[acyl-carrier-protein] dehydrogenase MbtN
The deposited structure of PDB entry 4xvx contains 2 copies of Pfam domain PF02770 (Acyl-CoA dehydrogenase, middle domain) in Acyl-[acyl-carrier-protein] dehydrogenase MbtN. Showing 1 copy in chain B.

PF02771
Domain description: Acyl-CoA dehydrogenase, N-terminal domain
Occurring in:
  1. Acyl-[acyl-carrier-protein] dehydrogenase MbtN

InterPro InterPro annotations
IPR036250
Domain description: Acyl-CoA dehydrogenase-like, C-terminal
Occurring in:
  1. Acyl-[acyl-carrier-protein] dehydrogenase MbtN
IPR009075
Domain description: Acyl-CoA dehydrogenase/oxidase, C-terminal
Occurring in:
  1. Acyl-[acyl-carrier-protein] dehydrogenase MbtN
IPR006091
Domain description: Acyl-CoA oxidase/dehydrogenase, middle domain
Occurring in:
  1. Acyl-[acyl-carrier-protein] dehydrogenase MbtN
IPR046373
Domain description: Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
Occurring in:
  1. Acyl-[acyl-carrier-protein] dehydrogenase MbtN
IPR009100
Domain description: Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
Occurring in:
  1. Acyl-[acyl-carrier-protein] dehydrogenase MbtN
IPR037069
Domain description: Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
Occurring in:
  1. Acyl-[acyl-carrier-protein] dehydrogenase MbtN

Structure domains

CATH CATH domains
1.20.140.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Butyryl-CoA Dehydrogenase, subunit A; domain 3
Homology: Butyryl-CoA Dehydrogenase, subunit A, domain 3
Occurring in:
  1. Acyl-[acyl-carrier-protein] dehydrogenase MbtN
The deposited structure of PDB entry 4xvx contains 2 copies of CATH domain 1.20.140.10 (Butyryl-CoA Dehydrogenase, subunit A; domain 3) in Acyl-[acyl-carrier-protein] dehydrogenase MbtN. Showing 1 copy in chain B.
2.40.110.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Butyryl-CoA Dehydrogenase, subunit A; domain 2
Homology: Butyryl-CoA Dehydrogenase, subunit A, domain 2
Occurring in:
  1. Acyl-[acyl-carrier-protein] dehydrogenase MbtN
The deposited structure of PDB entry 4xvx contains 2 copies of CATH domain 2.40.110.10 (Butyryl-CoA Dehydrogenase, subunit A; domain 2) in Acyl-[acyl-carrier-protein] dehydrogenase MbtN. Showing 1 copy in chain B.
1.10.540.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Butyryl-Coa Dehydrogenase, subunit A; domain 1
Homology: Acyl-CoA dehydrogenase/oxidase, N-terminal domain
Occurring in:
  1. Acyl-[acyl-carrier-protein] dehydrogenase MbtN
The deposited structure of PDB entry 4xvx contains 2 copies of CATH domain 1.10.540.10 (Butyryl-Coa Dehydrogenase, subunit A; domain 1) in Acyl-[acyl-carrier-protein] dehydrogenase MbtN. Showing 1 copy in chain B.

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