› 4xzp

X-ray diffraction
1.48Å resolution

Crystal structure of the N-terminal domain of human galectin-4

Released:
DOI: 10.2210/pdb4xzp/pdb
PDB entry 4xzp coloured by chain, front view.
PDB entry 4xzp coloured by chain, side view.
PDB entry 4xzp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Full-length model of the human galectin-4 and insights into dynamics of inter-domain communication.
Rustiguel JK, Soares RO, Meisburger SP, Davis KM, Malzbender KL, Ando N, Dias-Baruffi M, Nonato MC
OpenAccess logo Sci Rep 6 33633 (2016)
PMID: 27642006

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157475 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-4 Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 19.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56470 (Residues: 1-152; Coverage: 47%)
Gene name: LGALS4
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P6122
Unit cell:
a: 72.55Å b: 72.55Å c: 110.302Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.15 0.148 0.184
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Galectins in Cancer and the Microenvironment: Functional Roles, Therapeutic Developments, and Perspectives.
Li et al. (2021)
7 other articles

1 mention without citation

Full-length model of the human galectin-4 and insights into dynamics of inter-domain communication.
Rustiguel et al. (2016)