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Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg(2+)-GDP.

Serbzhinskiy DA, Clifton MC, Sankaran B, Staker BL, Edwards TE, Myler PJ
Acta Crystallogr F Struct Biol Commun 71 594-9 (2015)
Cited: 19 times
EuropePMC logo PMID: 25945714

Abstract

Entamoeba histolytica is the etiological agent of amebiasis, a diarrheal disease which causes amoebic liver abscesses and amoebic colitis. Approximately 50 million people are infected worldwide with E. histolytica. With only 10% of infected people developing symptomatic amebiasis, there are still an estimated 100,000 deaths each year. Because of the emergence of resistant strains of the parasite, it is necessary to find a treatment which would be a proper response to this challenge. ADP-ribosylation factor (ARF) is a member of the ARF family of GTP-binding proteins. These proteins are ubiquitous in eukaryotic cells; they generally associate with cell membranes and regulate vesicular traffic and intracellular signalling. The crystal structure of ARF1 from E. histolytica has been determined bound to magnesium and GDP at 1.8 Å resolution. Comparison with other structures of eukaryotic ARF proteins shows a highly conserved structure and supports the interswitch toggle mechanism of communicating the conformational state to partner proteins.

Articles - 4y0v mentioned but not cited (1)

  1. Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg(2+)-GDP. Serbzhinskiy DA, Clifton MC, Sankaran B, Staker BL, Edwards TE, Myler PJ. Acta Crystallogr F Struct Biol Commun 71 594-599 (2015)


Articles citing this publication (18)

  1. Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation. Ge X, Gong H, Dumas K, Litwin J, Phillips JJ, Waisfisz Q, Weiss MM, Hendriks Y, Stuurman KE, Nelson SF, Grody WW, Lee H, Kwok PY, Shieh JT. NPJ Genom Med 1 16036 (2016)
  2. Recombinant protein of Haemonchus contortus small GTPase ADP-ribosylation factor 1 (HcARF1) modulate the cell mediated immune response in vitro. Gadahi JA, Ehsan M, Wang S, Zhang Z, Yan R, Song X, Xu L, Li X. Oncotarget 8 112211-112221 (2017)
  3. Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1. Dubey R, Staker BL, Foe IT, Bogyo M, Myler PJ, Ngô HM, Gubbels MJ. Mol Microbiol 103 618-634 (2017)
  4. Phosphorylation of eukaryotic initiation factor-2α in response to endoplasmic reticulum and nitrosative stress in the human protozoan parasite, Entamoeba histolytica. Walters HA, Welter BH, Sullivan WJ, Temesvari LA. Mol Biochem Parasitol 234 111223 (2019)
  5. Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents. Helgren TR, Chen C, Wangtrakuldee P, Edwards TE, Staker BL, Abendroth J, Sankaran B, Housley NA, Myler PJ, Audia JP, Horn JR, Hagen TJ. Bioorg Med Chem 25 813-824 (2017)
  6. Crystal structure of a hypothetical protein from Giardia lamblia. Beard DK, Bristol S, Cosby K, Davis A, Manning C, Perry L, Snapp L, Toy A, Wheeler K, Young J, Staker B, Arakaki TL, Abendroth J, Subrahamanian S, Edwards TE, Myler PJ, Asojo OA. Acta Crystallogr F Struct Biol Commun 78 59-65 (2022)
  7. The crystal structure of dihydrodipicolinate reductase from the human-pathogenic bacterium Bartonella henselae strain Houston-1 at 2.3 Å resolution. Cala AR, Nadeau MT, Abendroth J, Staker BL, Reers AR, Weatherhead AW, Dobson RC, Myler PJ, Hudson AO. Acta Crystallogr F Struct Biol Commun 72 885-891 (2016)
  8. Crystal structure of a putative short-chain dehydrogenase/reductase from Paraburkholderia xenovorans. Davidson J, Nicholas K, Young J, Conrady DG, Mayclin S, Subramanian S, Staker BL, Myler PJ, Asojo OA. Acta Crystallogr F Struct Biol Commun 78 25-30 (2022)
  9. Identification of P218 as a potent inhibitor of Mycobacterium ulcerans DHFR. Riboldi GP, Zigweid R, Myler PJ, Mayclin SJ, Couñago RM, Staker BL. RSC Med Chem 12 103-109 (2021)
  10. Proteomic and Functional Analysis of the Effects of Quinoxaline Derivatives on Entamoeba histolytica. Avila-Bonilla RG, López-Sandoval Á, Soto-Sánchez J, Marchat LA, Rivera G, Medina-Contreras O, Ramírez-Moreno E. Front Cell Infect Microbiol 12 887647 (2022)
  11. A neurodevelopmental disorder associated with an activating de novo missense variant in ARF1. Ishida M, Otero MG, Freeman C, Sánchez-Lara PA, Guardia CM, Pierson TM, Bonifacino JS. Hum Mol Genet 32 1162-1174 (2023)
  12. Crystal structure of a short-chain dehydrogenase/reductase from Burkholderia phymatum in complex with NAD. Alenazi J, Mayclin S, Subramanian S, Myler PJ, Asojo OA. Acta Crystallogr F Struct Biol Commun 78 52-58 (2022)
  13. Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx. Maddy J, Staker BL, Subramanian S, Abendroth J, Edwards TE, Myler PJ, Hybiske K, Asojo OA. Acta Crystallogr F Struct Biol Commun 78 135-142 (2022)
  14. Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei. Beard DK, Subramanian S, Abendroth J, Dranow DM, Edwards TE, Myler PJ, Asojo OA. Acta Crystallogr F Struct Biol Commun 78 45-51 (2022)
  15. Crystal structures of FolM alternative dihydrofolate reductase 1 from Brucella suis and Brucella canis. Porter I, Neal T, Walker Z, Hayes D, Fowler K, Billups N, Rhoades A, Smith C, Smith K, Staker BL, Dranow DM, Mayclin SJ, Subramanian S, Edwards TE, Myler PJ, Asojo OA. Acta Crystallogr F Struct Biol Commun 78 31-38 (2022)
  16. Crystal structures of glutamyl-tRNA synthetase from Elizabethkingia anopheles and E. meningosepticum. Brooks L, Subramanian S, Dranow DM, Mayclin SJ, Myler PJ, Asojo OA. Acta Crystallogr F Struct Biol Commun 78 306-312 (2022)
  17. Identification of and Structural Insights into Hit Compounds Targeting N-Myristoyltransferase for Cryptosporidium Drug Development. Fenwick MK, Reers AR, Liu Y, Zigweid R, Sankaran B, Shin J, Hulverson MA, Hammerson B, Fernández Álvaro E, Myler PJ, Kaushansky A, Van Voorhis WC, Fan E, Staker BL. ACS Infect Dis 9 1821-1833 (2023)
  18. Structure-Guided Discovery of N5-CAIR Mutase Inhibitors. Belfon KKJ, Sharma N, Zigweid R, Bolejack M, Davies D, Edwards TE, Myler PJ, French JB. Biochemistry 62 2587-2596 (2023)


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