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The crystal structure of the G45V mutant of human GlnRS

Source organism: Homo sapiens
Biochemical function: protein kinase binding
Biological process: negative regulation of apoptotic signaling pathway
Cellular component: protein-containing complex

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EC 6.1.1.18: Glutamine--tRNA ligase

Reaction catalysed:
ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)
Systematic name:
L-glutamine:tRNA(Gln) ligase (AMP-forming)
Alternative Name(s):
  • GlnRS
  • Glutamate-tRNA ligase
  • Glutamine translase
  • Glutamine-tRNA synthetase
  • Glutaminyl ribonucleic acid
  • Glutaminyl-tRNA synthetase
  • Glutaminyl-transfer RNA synthetase
  • Glutaminyl-transfer ribonucleate synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF20974
Domain description: tRNA synthetases class I (E and Q), anti-codon binding domain
Occurring in:
  1. Glutamine--tRNA ligase
The deposited structure of PDB entry 4ye9 contains 1 copy of Pfam domain PF20974 (tRNA synthetases class I (E and Q), anti-codon binding domain) in Glutamine--tRNA ligase. Showing 1 copy in chain A.

PF03950
Domain description: tRNA synthetases class I (E and Q), anti-codon binding domain
Occurring in:
  1. Glutamine--tRNA ligase
The deposited structure of PDB entry 4ye9 contains 1 copy of Pfam domain PF03950 (tRNA synthetases class I (E and Q), anti-codon binding domain) in Glutamine--tRNA ligase. Showing 1 copy in chain A.

PF00749
Domain description: tRNA synthetases class I (E and Q), catalytic domain
Occurring in:
  1. Glutamine--tRNA ligase
The deposited structure of PDB entry 4ye9 contains 1 copy of Pfam domain PF00749 (tRNA synthetases class I (E and Q), catalytic domain) in Glutamine--tRNA ligase. Showing 1 copy in chain A.

PF04557
Domain description: Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
Occurring in:
  1. Glutamine--tRNA ligase
The deposited structure of PDB entry 4ye9 contains 1 copy of Pfam domain PF04557 (Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 ) in Glutamine--tRNA ligase. Showing 1 copy in chain A.

PF04558
Domain description: Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
Occurring in:
  1. Glutamine--tRNA ligase
The deposited structure of PDB entry 4ye9 contains 1 copy of Pfam domain PF04558 (Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 ) in Glutamine--tRNA ligase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000924
Domain description: Glutamyl/glutaminyl-tRNA synthetase
Occurring in:
  1. Glutamine--tRNA ligase
IPR020056
Domain description: Large ribosomal subunit protein bL25/Gln-tRNA synthetase, N-terminal
Occurring in:
  1. Glutamine--tRNA ligase
IPR020059
Domain description: Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
Occurring in:
  1. Glutamine--tRNA ligase
IPR011035
Domain description: Large ribosomal subunit protein bL25/Gln-tRNA synthetase, anti-codon-binding domain superfamily
Occurring in:
  1. Glutamine--tRNA ligase
IPR001412
Domain description: Aminoacyl-tRNA synthetase, class I, conserved site
Occurring in:
  1. Glutamine--tRNA ligase
IPR004514
Domain description: Glutamine-tRNA synthetase
Occurring in:
  1. Glutamine--tRNA ligase
IPR020058
Domain description: Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
Occurring in:
  1. Glutamine--tRNA ligase
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Glutamine--tRNA ligase
IPR007638
Domain description: Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2
Occurring in:
  1. Glutamine--tRNA ligase
IPR042559
Domain description: Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2
Occurring in:
  1. Glutamine--tRNA ligase
IPR007639
Domain description: Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal
Occurring in:
  1. Glutamine--tRNA ligase
IPR042558
Domain description: Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1
Occurring in:
  1. Glutamine--tRNA ligase

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