Function and Biology

Structural Insights Into the Neutralization Properties of a Human Anti-Interferon Monoclonal Antibody

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: negative regulation of T-helper 2 cell cytokine production
Cellular component: extracellular region

Sequence families

Pfam Protein families (Pfam)
PF00143
Domain description: Interferon alpha/beta domain
Occurring in:
  1. Interferon alpha-2
The deposited structure of PDB entry 4ypg contains 2 copies of Pfam domain PF00143 (Interferon alpha/beta domain) in Interferon alpha-2. Showing 1 copy in chain D.

PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. Ig-like domain-containing protein
The deposited structure of PDB entry 4ypg contains 2 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Ig-like domain-containing protein. Showing 1 copy in chain A.

PF07686
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Ig-like domain-containing protein
The deposited structure of PDB entry 4ypg contains 2 copies of Pfam domain PF07686 (Immunoglobulin V-set domain) in Ig-like domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000471
Domain description: Interferon alpha/beta/delta
Occurring in:
  1. Interferon alpha-2
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Ig-like domain-containing protein
  2. Sifalimumab heavy chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Ig-like domain-containing protein
  2. Sifalimumab heavy chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Ig-like domain-containing protein
  2. Sifalimumab heavy chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Ig-like domain-containing protein
  2. Sifalimumab heavy chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Ig-like domain-containing protein
  2. Sifalimumab heavy chain
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Ig-like domain-containing protein
  2. Sifalimumab heavy chain
IPR009079
Domain description: Four-helical cytokine-like, core
Occurring in:
  1. Interferon alpha-2
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Ig-like domain-containing protein
  2. Sifalimumab heavy chain

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Ig-like domain-containing protein
  2. Sifalimumab heavy chain
The deposited structure of PDB entry 4ypg contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig-like domain-containing protein. Showing 2 copies in chain A.
The deposited structure of PDB entry 4ypg contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Sifalimumab heavy chain. Showing 2 copies in chain B.
1.20.1250.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Growth Hormone; Chain: A;
Homology: Growth Hormone; Chain: A;
Occurring in:
  1. Interferon alpha-2
The deposited structure of PDB entry 4ypg contains 2 copies of CATH domain 1.20.1250.10 (Growth Hormone; Chain: A;) in Interferon alpha-2. Showing 1 copy in chain D.