EC 1.3.5.1: Succinate dehydrogenase (quinone)
Reaction catalysed:
Succinate + a quinone = fumarate + a quinol
Systematic name:
Succinate:quinone oxidoreductase
Alternative Name(s):
- Complex II
- SDH
- Succinate dehydrogenase (ubiquinone)
- Succinate dehydrogenase complex
- Succinate:ubiquinone oxidoreductase
- Succinic dehydrogenase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
PF01127
Domain description:
Succinate dehydrogenase/Fumarate reductase transmembrane subunit
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4ytm</span> contains 2 copies of Pfam domain <span class='highlight'>PF01127 (Succinate dehydrogenase/Fumarate reductase transmembrane subunit)</span> in <span class='highlight'>Succinate dehydrogenase [ubiquinone] cytochrome b large subunit, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>C</span>. The deposited structure of PDB entry 4ytm contains 2 copies of Pfam domain PF01127 (Succinate dehydrogenase/Fumarate reductase transmembrane subunit) in Succinate dehydrogenase [ubiquinone] cytochrome b large subunit, mitochondrial. Showing 1 copy in chain C.](https://www.ebi.ac.uk/pdbe/static/entry/4ytm_3_C_Pfam_PF01127_image-200x200.png)
InterPro annotations
IPR034804
Domain description:
Fumarate reductase/succinate dehydrogenase, transmembrane subunit
Occurring in:
Occurring in:
IPR007992
Domain description:
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybS
Occurring in:
Occurring in:
IPR018495
Domain description:
Succinate dehydrogenase, cytochrome b subunit, conserved site
Occurring in:
Occurring in:
IPR027477
Domain description:
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily
Occurring in:
Occurring in:
IPR000701
Domain description:
Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit
Occurring in:
Occurring in:
IPR004489
Domain description:
Succinate dehydrogenase/fumarate reductase iron-sulphur protein
Occurring in:
Occurring in:
IPR015939
Domain description:
Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
Occurring in:
Occurring in:
IPR037099
Domain description:
Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily
Occurring in:
Occurring in:
IPR003952
Domain description:
Fumarate reductase/succinate dehydrogenase, FAD-binding site
Occurring in:
Occurring in:
IPR014006
Domain description:
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
Occurring in:
Occurring in:
Structure domains
CATH domains
1.20.1300.10
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
3 helical TM bundles of succinate and fumarate reductases
Homology:
Fumarate reductase/succinate dehydrogenase, transmembrane subunit
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4ytm</span> contains 2 copies of CATH domain <span class='highlight'>1.20.1300.10 (3 helical TM bundles of succinate and fumarate reductases)</span> in <span class='highlight'>Succinate dehydrogenase [ubiquinone] cytochrome b large subunit, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>C</span>. The deposited structure of PDB entry 4ytm contains 2 copies of CATH domain 1.20.1300.10 (3 helical TM bundles of succinate and fumarate reductases) in Succinate dehydrogenase [ubiquinone] cytochrome b large subunit, mitochondrial. Showing 1 copy in chain C.](https://www.ebi.ac.uk/pdbe/static/entry/4ytm_3_C_CATH_1.20.1300.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4ytm</span> contains 2 copies of CATH domain <span class='highlight'>1.20.1300.10 (3 helical TM bundles of succinate and fumarate reductases)</span> in <span class='highlight'>Succinate dehydrogenase [ubiquinone] cytochrome b small subunit 1, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>D</span>. The deposited structure of PDB entry 4ytm contains 2 copies of CATH domain 1.20.1300.10 (3 helical TM bundles of succinate and fumarate reductases) in Succinate dehydrogenase [ubiquinone] cytochrome b small subunit 1, mitochondrial. Showing 1 copy in chain D.](https://www.ebi.ac.uk/pdbe/static/entry/4ytm_4_D_CATH_1.20.1300.10_image-200x200.png)
3.50.50.60
Class:
Alpha Beta
Architecture:
3-Layer(bba) Sandwich
Topology:
FAD/NAD(P)-binding domain
Homology:
FAD/NAD(P)-binding domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4ytm</span> contains 2 copies of CATH domain <span class='highlight'>3.50.50.60 (FAD/NAD(P)-binding domain)</span> in <span class='highlight'>Succinate dehydrogenase [rhodoquinone] flavoprotein subunit 1, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4ytm contains 2 copies of CATH domain 3.50.50.60 (FAD/NAD(P)-binding domain) in Succinate dehydrogenase [rhodoquinone] flavoprotein subunit 1, mitochondrial. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4ytm_1_A_CATH_3.50.50.60_image-200x200.png)
1.10.1060.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
Homology:
Alpha-helical ferredoxin
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4ytm</span> contains 2 copies of CATH domain <span class='highlight'>1.10.1060.10 (Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2)</span> in <span class='highlight'>Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>F</span>. The deposited structure of PDB entry 4ytm contains 2 copies of CATH domain 1.10.1060.10 (Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2) in Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial. Showing 1 copy in chain F.](https://www.ebi.ac.uk/pdbe/static/entry/4ytm_2_F_CATH_1.10.1060.10_image-200x200.png)
3.10.20.30
Class:
Alpha Beta
Architecture:
Roll
Topology:
Ubiquitin-like (UB roll)
Homology:
Ubiquitin-like (UB roll)
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4ytm</span> contains 2 copies of CATH domain <span class='highlight'>3.10.20.30 (Ubiquitin-like (UB roll))</span> in <span class='highlight'>Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>F</span>. The deposited structure of PDB entry 4ytm contains 2 copies of CATH domain 3.10.20.30 (Ubiquitin-like (UB roll)) in Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial. Showing 1 copy in chain F.](https://www.ebi.ac.uk/pdbe/static/entry/4ytm_2_F_CATH_3.10.20.30_image-200x200.png)
4.10.80.40
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Rhinovirus 14, subunit 4
Homology:
succinate dehydrogenase protein domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4ytm</span> contains 2 copies of CATH domain <span class='highlight'>4.10.80.40 (Rhinovirus 14, subunit 4)</span> in <span class='highlight'>Succinate dehydrogenase [rhodoquinone] flavoprotein subunit 1, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4ytm contains 2 copies of CATH domain 4.10.80.40 (Rhinovirus 14, subunit 4) in Succinate dehydrogenase [rhodoquinone] flavoprotein subunit 1, mitochondrial. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4ytm_1_A_CATH_4.10.80.40_image-200x200.png)
1.20.58.100
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homology:
Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4ytm</span> contains 2 copies of CATH domain <span class='highlight'>1.20.58.100 (Methane Monooxygenase Hydroxylase; Chain G, domain 1)</span> in <span class='highlight'>Succinate dehydrogenase [rhodoquinone] flavoprotein subunit 1, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4ytm contains 2 copies of CATH domain 1.20.58.100 (Methane Monooxygenase Hydroxylase; Chain G, domain 1) in Succinate dehydrogenase [rhodoquinone] flavoprotein subunit 1, mitochondrial. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4ytm_1_A_CATH_1.20.58.100_image-200x200.png)