› 4yz7

X-ray diffraction
1.96Å resolution

Crystal structure of Piratoxin I (PrTX-I) complexed to aristolochic acid

Released:
DOI: 10.2210/pdb4yz7/pdb
PDB entry 4yz7 coloured by chain, front view.
PDB entry 4yz7 coloured by chain, side view.
PDB entry 4yz7 coloured by chain, top view.
Source organism: Bothrops pirajai
Primary publication:
Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids.
Fernandes CA, Cardoso FF, Cavalcante WG, Soares AM, Dal-Pai M, Gallacci M, Fontes MR
OpenAccess logo PLoS One 10 e0133370 (2015)
PMID: 26192963

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157678 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 homolog piratoxin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 121 amino acids
Theoretical weight: 13.75 KDa
Source organism: Bothrops pirajai
UniProt:
  • Canonical: P58399 (Residues: 1-121; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

3 bound ligands:
Ligand SO4 5 x SO4
Ligand PE4 1 x PE4
Ligand 9AR 1 x 9AR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: P21212
Unit cell:
a: 68.317Å b: 70.931Å c: 44.048Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.173 0.235

Quick links

Citations

6 review citations

Secreted Phospholipases A₂ from Animal Venoms in Pain and Analgesia.
Zambelli et al. (2017)
5 more

3 mentions without citation

Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920).
Salvador et al. (2019)
2 more