EC 3.1.26.n2: Argonaute-2
Reaction catalysed:
Endonucleolytic cleavage to 5'-phosphomonoester
Systematic name:
-
Alternative Name(s):
- Argonaute RISC catalytic component 2
- Eukaryotic translation initiation factor 2C 2
GO terms
Biochemical function:
- mRNA cap binding
- endoribonuclease activity, cleaving miRNA-paired mRNA
- endoribonuclease activity, cleaving siRNA-paired mRNA
- regulatory RNA binding
- metal ion binding
- mRNA 3'-UTR AU-rich region binding
- miRNA binding
- siRNA binding
- RNA endonuclease activity, producing 5'-phosphomonoesters
- protein binding
- RNA endonuclease activity
- endonuclease activity
- translation initiation factor activity
- mRNA binding
- single-stranded RNA binding
- double-stranded RNA binding
- RNA binding
- nucleic acid binding
- core promoter sequence-specific DNA binding
- RNA polymerase II complex binding
- RNA 7-methylguanosine cap binding
Biological process:
- positive regulation of trophoblast cell migration
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- siRNA-mediated gene silencing by mRNA destabilization
- regulation of synapse maturation
- RISC complex assembly
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- negative regulation of translational initiation
- positive regulation of transcription by RNA polymerase II
- positive regulation of angiogenesis
- positive regulation of translation
- negative regulation of amyloid precursor protein biosynthetic process
- miRNA-mediated gene silencing by mRNA destabilization
- miRNA-mediated gene silencing by inhibition of translation
- miRNA processing
- regulatory ncRNA-mediated post-transcriptional gene silencing
- P-body assembly
- pre-miRNA processing
- regulatory ncRNA-mediated gene silencing
- siRNA processing
- positive regulation of gene expression
- miRNA metabolic process
- post-embryonic development
- regulation of translation
- translational initiation
- translation
- regulation of DNA-templated transcription
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotationsStructure domains
CATH domains
3.30.420.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Nucleotidyltransferase; domain 5
Homology:
Ribonuclease H-like superfamily/Ribonuclease H
Occurring in:
3.40.50.2300
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
Rossmann fold
Occurring in:
