› 4zc4

X-ray diffraction
1.86Å resolution

Crystal structure of LARP1-unique domain DM15

Released:
DOI: 10.2210/pdb4zc4/pdb
PDB entry 4zc4 coloured by chain, front view.
PDB entry 4zc4 coloured by chain, side view.
PDB entry 4zc4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence.
Lahr RM, Mack SM, Héroux A, Blagden SP, Bousquet-Antonelli C, Deragon JM, Berman AJ
OpenAccess logo Nucleic Acids Res 43 8077-88 (2015)
PMID: 26206669

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180198 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
La-related protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 162 amino acids
Theoretical weight: 19.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6PKG0 (Residues: 873-1023; Coverage: 14%)
Gene names: KIAA0731, LARP, LARP1
Sequence domains: LARP1 HEAT repeat region

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21
Unit cell:
a: 77.906Å b: 61.759Å c: 85.336Å
α: 90° β: 116.2° γ: 90°
R-values:
R R work R free
0.182 0.182 0.214
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism.
Hoxhaj et al. (2020)
13 more

3 mentions without citation

The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence.
Lahr et al. (2015)
2 more