› 4ziq

X-ray diffraction
2.55Å resolution

Crystal structure of trypsin activated alpha-2-macroglobulin from Escherichia coli.

Released:
DOI: 10.2210/pdb4ziq/pdb
PDB entry 4ziq coloured by chain, front view.
PDB entry 4ziq coloured by chain, side view.
PDB entry 4ziq coloured by chain, top view.
Source organism: Escherichia coli K-12
Primary publication:
Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition.
Garcia-Ferrer I, Arêde P, Gómez-Blanco J, Luque D, Duquerroy S, Castón JR, Goulas T, Gomis-Rüth FX
Proc Natl Acad Sci U S A 112 8290-5 (2015)
PMID: 26100869

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160111 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC, ESRF BEAMLINE ID23-1, ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 274.28Å b: 95.36Å c: 81.09Å
α: 90° β: 104.77° γ: 90°
R-values:
R R work R free
0.19 0.19 0.221
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Oxidation of proteins: is it a programmed process?
Rosenfeld et al. (2018)
1 more

2 mentions without citation

Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition.
Garcia-Ferrer et al. (2015)
1 more