Function and Biology

Crystal structure of Merlin-FERM and Lats2

Source organism: Homo sapiens
Biochemical function: cytoskeletal protein binding
Biological process: not assigned
Cellular component: cytoskeleton

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF09380
Domain description: FERM C-terminal PH-like domain
Occurring in:
  1. Merlin
The deposited structure of PDB entry 4zri contains 2 copies of Pfam domain PF09380 (FERM C-terminal PH-like domain) in Merlin. Showing 1 copy in chain A.

PF00373
Domain description: FERM central domain
Occurring in:
  1. Merlin
The deposited structure of PDB entry 4zri contains 2 copies of Pfam domain PF00373 (FERM central domain) in Merlin. Showing 1 copy in chain A.

PF09379
Domain description: FERM N-terminal domain
Occurring in:
  1. Merlin
The deposited structure of PDB entry 4zri contains 2 copies of Pfam domain PF09379 (FERM N-terminal domain ) in Merlin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000798
Domain description: Ezrin/radixin/moesin-like
Occurring in:
  1. Merlin
IPR019749
Domain description: Band 4.1 domain
Occurring in:
  1. Merlin
IPR018980
Domain description: FERM, C-terminal PH-like domain
Occurring in:
  1. Merlin
IPR019748
Domain description: FERM central domain
Occurring in:
  1. Merlin
IPR019747
Domain description: FERM conserved site
Occurring in:
  1. Merlin
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Merlin
IPR041789
Domain description: ERM family, FERM domain C-lobe
Occurring in:
  1. Merlin
IPR035963
Domain description: FERM superfamily, second domain
Occurring in:
  1. Merlin
IPR014352
Domain description: FERM/acyl-CoA-binding protein superfamily
Occurring in:
  1. Merlin
IPR018979
Domain description: FERM, N-terminal
Occurring in:
  1. Merlin
IPR000299
Domain description: FERM domain
Occurring in:
  1. Merlin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Merlin
IPR011174
Domain description: Ezrin/radixin/moesin
Occurring in:
  1. Merlin

Structure domains

CATH CATH domains
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Merlin
The deposited structure of PDB entry 4zri contains 2 copies of CATH domain 2.30.29.30 (PH-domain like) in Merlin. Showing 1 copy in chain A.
1.20.80.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Acyl-CoA Binding Protein
Homology: Acyl-CoA Binding Protein
Occurring in:
  1. Merlin
The deposited structure of PDB entry 4zri contains 2 copies of CATH domain 1.20.80.10 (Acyl-CoA Binding Protein) in Merlin. Showing 1 copy in chain A.
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Merlin
The deposited structure of PDB entry 4zri contains 2 copies of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Merlin. Showing 1 copy in chain A.