Function and Biology

Structure of human ALDH7A1 complexed with NAD+ in space group P4212

Source organism: Homo sapiens
Biochemical function: identical protein binding
Biological process: choline catabolic process
Cellular component: extracellular exosome

EC 1.2.1.31: L-aminoadipate-semialdehyde dehydrogenase

Reaction catalysed:
(1a) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O (spontaneous)
Systematic name:
(S)-2-amino-6-oxohexanoate:NAD(P)(+) 6-oxidoreductase
Alternative Name(s):
  • 2-aminoadipate semialdehyde dehydrogenase
  • 2-aminoadipic semialdehyde dehydrogenase
  • Alpha-aminoadipate reductase
  • Alpha-aminoadipate-semialdehyde dehydrogenase
  • Aminoadipate semialdehyde dehydrogenase
  • L-2-aminoadipate-6-semialdehyde:NAD(P)(+) 6-oxidoreductase
  • L-alpha-aminoadipate delta-semialdehyde oxidoreductase
  • L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase
  • L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase

EC 1.2.1.8: Betaine-aldehyde dehydrogenase

Reaction catalysed:
Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH
Systematic name:
Betaine-aldehyde:NAD(+) oxidoreductase
Alternative Name(s):
  • BADH
  • BetB
  • Betaine aldehyde dehydrogenase
  • Betaine aldehyde oxidase

EC 1.2.1.3: Aldehyde dehydrogenase (NAD(+))

Reaction catalysed:
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
Systematic name:
Aldehyde:NAD(+) oxidoreductase
Alternative Name(s):
  • CoA-independent aldehyde dehydrogenase
  • NAD-aldehyde dehydrogenase
  • NAD-dependent 4-hydroxynonenal dehydrogenase
  • NAD-dependent aldehyde dehydrogenase
  • NAD-linked aldehyde dehydrogenase
  • Propionaldehyde dehydrogenase
  • m-methylbenzaldehyde dehydrogenase

Sequence family

Pfam Protein family (Pfam)
PF00171
Domain description: Aldehyde dehydrogenase family
Occurring in:
  1. Alpha-aminoadipic semialdehyde dehydrogenase
The deposited structure of PDB entry 4zvy contains 2 copies of Pfam domain PF00171 (Aldehyde dehydrogenase family) in Alpha-aminoadipic semialdehyde dehydrogenase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR016163
Domain description: Aldehyde dehydrogenase, C-terminal
Occurring in:
  1. Alpha-aminoadipic semialdehyde dehydrogenase
IPR029510
Domain description: Aldehyde dehydrogenase, glutamic acid active site
Occurring in:
  1. Alpha-aminoadipic semialdehyde dehydrogenase
IPR015590
Domain description: Aldehyde dehydrogenase domain
Occurring in:
  1. Alpha-aminoadipic semialdehyde dehydrogenase
IPR016162
Domain description: Aldehyde dehydrogenase, N-terminal
Occurring in:
  1. Alpha-aminoadipic semialdehyde dehydrogenase
IPR016161
Domain description: Aldehyde/histidinol dehydrogenase
Occurring in:
  1. Alpha-aminoadipic semialdehyde dehydrogenase
IPR044638
Domain description: Aldehyde dehydrogenase family 7 member A1-like
Occurring in:
  1. Alpha-aminoadipic semialdehyde dehydrogenase

Structure domains

CATH CATH domains
3.40.605.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aldehyde Dehydrogenase; Chain A, domain 1
Homology: Aldehyde Dehydrogenase; Chain A, domain 1
Occurring in:
  1. Alpha-aminoadipic semialdehyde dehydrogenase
The deposited structure of PDB entry 4zvy contains 2 copies of CATH domain 3.40.605.10 (Aldehyde Dehydrogenase; Chain A, domain 1) in Alpha-aminoadipic semialdehyde dehydrogenase. Showing 1 copy in chain B.
3.40.309.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aldehyde Dehydrogenase; Chain A, domain 2
Homology: Aldehyde Dehydrogenase; Chain A, domain 2
Occurring in:
  1. Alpha-aminoadipic semialdehyde dehydrogenase
The deposited structure of PDB entry 4zvy contains 2 copies of CATH domain 3.40.309.10 (Aldehyde Dehydrogenase; Chain A, domain 2) in Alpha-aminoadipic semialdehyde dehydrogenase. Showing 1 copy in chain B.