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High resolution structure of M23 peptidase LytM with substrate analogue

Source organism: Staphylococcus aureus subsp. aureus NCTC 8325
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.4.24.75: Lysostaphin

Reaction catalysed:
Hydrolysis of the -Gly-|-Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell wall peptidoglycans.
Alternative Name(s):
  • Glycyl-glycine endopeptidase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01551
Domain description: Peptidase family M23
Occurring in:
  1. Glycyl-glycine endopeptidase LytM
The deposited structure of PDB entry 4zyb contains 4 copies of Pfam domain PF01551 (Peptidase family M23) in Glycyl-glycine endopeptidase LytM. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR011055
Domain description: Duplicated hybrid motif
Occurring in:
  1. Glycyl-glycine endopeptidase LytM
IPR016047
Domain description: Peptidase M23
Occurring in:
  1. Glycyl-glycine endopeptidase LytM

Structure domain

CATH CATH domain
2.70.70.10
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: Glucose Permease (Domain IIA)
Homology: Glucose Permease (Domain IIA)
Occurring in:
  1. Glycyl-glycine endopeptidase LytM
The deposited structure of PDB entry 4zyb contains 4 copies of CATH domain 2.70.70.10 (Glucose Permease (Domain IIA)) in Glycyl-glycine endopeptidase LytM. Showing 1 copy in chain A.

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