5a0q

Electron Microscopy
3.5Å resolution

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core

Released:
Source organism: Homo sapiens
Related structures: EMD-2981

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 28-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127173 (preferred)
Entry contents:
14 distinct polypeptide molecules
Macromolecules (14 distinct):
Proteasome subunit alpha type-6 Chains: A, O
Molecule details ›
Chains: A, O
Length: 246 amino acids
Theoretical weight: 27.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P60900 (Residues: 1-246; Coverage: 100%)
Gene names: PROS27, PSMA6
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit alpha type-2 Chains: B, P
Molecule details ›
Chains: B, P
Length: 234 amino acids
Theoretical weight: 25.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25787 (Residues: 1-234; Coverage: 100%)
Gene names: HC3, PSC3, PSMA2
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit alpha type-4 Chains: C, Q
Proteasome subunit alpha type-7 Chains: D, R
Proteasome subunit alpha type-5 Chains: E, S
Proteasome subunit alpha type-1 Chains: F, T
Proteasome subunit alpha type-3 Chains: G, U
Proteasome subunit beta type-6 Chains: H, V
Proteasome subunit beta type-7 Chains: I, W
Proteasome subunit beta type-3 Chains: J, X
Proteasome subunit beta type-2 Chains: K, Y
Proteasome subunit beta type-5 Chains: L, Z
Proteasome subunit beta type-1 Chains: M, a
Proteasome subunit beta type-4 Chains: N, b

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.5Å
Relevant EMDB volumes: EMD-2981