› 5afb

X-ray diffraction
2.16Å resolution

Crystal structure of the Latrophilin3 Lectin and Olfactomedin Domains

Released:
DOI: 10.2210/pdb5afb/pdb
PDB entry 5afb coloured by chain, front view.
PDB entry 5afb coloured by chain, side view.
PDB entry 5afb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of latrophilin-FLRT interaction.
Jackson VA, del Toro D, Carrasquero M, Roversi P, Harlos K, Klein R, Seiradake E
OpenAccess logo Structure 23 774-81 (2015)
PMID: 25728924

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190722 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adhesion G protein-coupled receptor L3 Chain: A
Molecule details ›
Chain: A
Length: 384 amino acids
Theoretical weight: 44.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9HAR2 (Residues: 24-395; Coverage: 26%)
Gene names: ADGRL3, KIAA0768, LEC3, LPHN3
Sequence domains:
Structure domains: Jelly Rolls

Ligands and Environments

4 bound ligands:
Ligand NAG 1 x NAG
Ligand NA 1 x NA
Ligand CA 1 x CA
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: I222
Unit cell:
a: 78.43Å b: 96.65Å c: 101.64Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.245
Expression system: Homo sapiens

Quick links

Citations

11 review citations

Adhesion G protein-coupled receptors in nervous system development and disease.
Langenhan et al. (2016)
10 more

11 mentions without citation

Towards an Understanding of Synapse Formation.
Südhof TC. (2018)
10 more