› 5az5

X-ray diffraction
2.4Å resolution

Crystal structure of human TLR8 in complex with MB-343

Released:
DOI: 10.2210/pdb5az5/pdb
PDB entry 5az5 coloured by chain, front view.
PDB entry 5az5 coloured by chain, side view.
PDB entry 5az5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tanji H, Ohto U, Shimizu T

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192550 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (5 distinct):
Toll-like receptor 8 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 811 amino acids
Theoretical weight: 92.84 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: Q9NR97 (Residues: 27-827; Coverage: 79%)
Gene names: TLR8, UNQ249/PRO286
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand MBL 4 x MBL
Ligand NAG 14 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 86.627Å b: 141.119Å c: 170.972Å
α: 90° β: 90.32° γ: 90°
R-values:
R R work R free
0.199 0.196 0.259
Expression system: Drosophila

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