› 5azv

X-ray diffraction
2.7Å resolution

Crystal structure of hPPARgamma ligand binding domain complexed with 17-oxoDHA

Released:
DOI: 10.2210/pdb5azv/pdb
PDB entry 5azv coloured by chain, front view.
PDB entry 5azv coloured by chain, side view.
PDB entry 5azv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
17-OxoDHA Is a PPARα/γ Dual Covalent Modifier and Agonist.
Egawa D, Itoh T, Akiyama Y, Saito T, Yamamoto K
ACS Chem Biol 11 2447-55 (2016)
PMID: 27337155

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 232-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 4M5 2 x 4M5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: C2
Unit cell:
a: 92.61Å b: 60.95Å c: 118.21Å
α: 90° β: 102.36° γ: 90°
R-values:
R R work R free
0.225 0.221 0.307
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Bioactive metabolites of docosahexaenoic acid.
Kuda O. (2017)
4 more

1 mention without citation

The nuclear receptor superfamily: A structural perspective.
Weikum et al. (2018)