› 5bp0

X-ray diffraction
2.4Å resolution

X-ray crystal structure of Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP) in complex with 5-Fluoronicotine (TI-4650)

Released:
DOI: 10.2210/pdb5bp0/pdb
PDB entry 5bp0 coloured by chain, front view.
PDB entry 5bp0 coloured by chain, side view.
PDB entry 5bp0 coloured by chain, top view.
Source organism: Lymnaea stagnalis
Entry authors: Bobango J, Sankaran B, Park JF, Wu J, Talley TT

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157653 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetylcholine-binding protein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 218 amino acids
Theoretical weight: 24.86 KDa
Source organism: Lymnaea stagnalis
Expression system: Homo sapiens
UniProt:
  • Canonical: P58154 (Residues: 20-229; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

3 bound ligands:
Ligand PO4 10 x PO4
Ligand FN1 8 x FN1
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21
Unit cell:
a: 82.47Å b: 129.04Å c: 122.43Å
α: 90° β: 106.28° γ: 90°
R-values:
R R work R free
0.2 0.198 0.248
Expression system: Homo sapiens

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